Control Study Of Cognitive Function Among Individuals At Ultra-High Risk Of Schizophrenia

Objective:Schizophrenia(schizophrenia,SCH)which is a severe mental illness and is characterized by inconsistance of feelings with external world.Schizophrenia and their first time attack exis significant cognitive impairments.This study aims to study the cognitive features among individuals at ultra-high risk of schizophrenia(UHR);while understand the factors influencing cognitive impairment;and deduce factors in addition to what is a risk factors for schizophrenia inferred ultra-high-risk groups to the transformation of schizophrenia.Methods:According to the ratio from 1:2,we selected 20 cases of UHR and 40 cases of FRS from first-degree relatives of patients with schizophrenia between June,2012 to November,2013 among outpatient and inpatient in Tianjin Mental Health Center;while we selected 40 cases among first-episode schizophrenia patients in the same period;and we selected 40 cases of heath individuals to be health control group(NC)at a university in Tianjin,secondary and community health volunteers.Stroop,CPT-IP,HVLT-R,BVMT-R,TMTA and DST were applied to evaluate the status of congnitive of each case.SPSS 17.0 software was used to do statistical analysis.Result:1.Among groups of UHR,total scores of PANSS and the number of life events are higher than that among FRS.2.With the comparison of HRS,only the average score of solve the problem factor of CSQ among UHR showes the significant higher(t = 2.41,P<0.001).3.The results of ANOVA analysis showes that average scores of each four cognitive tests among UHR,FRS,SCH and NC have significant differences(P<0.05),however besides the results of Stroop(w).4.Four pairwise comparison,the average scores of cognitive tests among UHR are no significant differences than that among FRS(P>0.05).The average score differences of each cognitive tests between FRS and SCH,and between SCH and NC are statistic significance(P<0.05)besides the results of Stroop(w)(P>0.05).The average score differences of each cognitive tests between UHR and SCH are statistic significance(P<0.05)besides the results of HVLT-R1,HVLT-R3 and HVLT-R(P>0.05).The average score differences of each cognitive tests between UHR and NC are statistic significance(P<0.05)besides the results of TMTA,BVMT-R3,CPT4D and Stroop(w)(P>0.05).The average score differences of each cognitive tests between FRS and NC are statistic significance(P<0.05)besides the results of TMTA,BVMT-R3,HVLT-R2 and Stroop(w)(P>0.05).5.For correlation analysis among UHR:The results of Age and education level,PANSS total score,GAF-M Currently score,family cohesion and family adaptability,self-blame coping style factors and fantasy factor scores significantly correlate with certain cognitive tests(P<0.05);however,that of solve problems,help with the rationalization of the various factors do not correlate with and cognitive test scores.6.With logistic regression analysis,17 cognitive tests pairwise comparison analysis of variance,the result showed that UHR group CPT average,FRS group average CPT coding and symbols were the risk factors for schizophrenia tendencies,OR values were 0.08,0.10,0.90,which have statistically significant(P<0.05).Conclusion:1.Compared to the first-degree relatives without psychosis risk syndrome,individuals at ultra-high-risk groups for schizophrenia have obvious psychiatric symptoms;more psychological stress events;and more use of immature coping style.2.In three dimensions of assessing cognitive function of attention capacity/alertness,learning and memory function,information processing speed,the severity of the ultra-high-risk groups for schizophrenia are located between schizophrenia and healthy normal population,and shows little difference with the first-degree relatives.3.For Ultra-high-risk populations,the cognitive impairment shows severer along with the younger for schizophrenia,lower of the education level,the more severity of psychiatric symptoms,poorer social and family functioning,and more frequency of use of immature coping.4.Attention dysfunction is a risk factor for individual of ultra-high-risk who transformats to schizophrenia.