Study On Two Ways Of Mechanical Ventilatory Assisting Neonatal Respiratory Distress Syndrome

ObjectsCompare two forms of assisted mechanical ventilation treatment of neonatal respiratory distress syndrome, by analyzing the advantages and disadvantages of the treatment of neonatal respiratory distress syndrome, the aim of which is to provide a scientific basis.MethodsIt is based on 248 cases of receiving mechanical ventilation adjuvant treatment of neonatal respiratory distress syndrome in a city Maternal and Child Care Service Hospital from February 2011-February 2015. It included 120 cases of the high-frequency oscillatory ventilation group and 128 cases of the conventional mechanical ventilation group, by observing the two groups of children with treatment, 1h,6h,24h,48h when the partial pressure of carbon dioxide (PaCO2), blood oxygen pressure (PaO2), oxygen concentration (FiO2), oxygenation index (OI); statistical cure rates and complication rates. Use SPSS 21.0 software for data processing, test level a= 0.05.Results1. There was no significant difference between the two groups under the pre-treatment of children PaCO2, PaO2, FiO2, OI (P> 0.05).2. Compared with previous treatment, after treatment, PaCO2, FiO2, and OI in both groups of children decreased significantly, and the PaO2 rises rapidly; all indicators are starting treatment fastest recovery within six hours, after 48 hours slowly to be stabilized, where the normal frequency group of children PaCO2, FiO2, OI at 48h acceptance by a ventilator-assisted therapy before treatment (69.48±6.16), (70.50± 7.23), (23.32±3.76), respectively, down to the time of 48h (37.01±2.16), (39.77± 3.82), (3.22±0.75). There is PaO2 (39.83±3.85) made before treatment to rise (70.03 ±4.85);during 48h PaCO2, FiO2,OI children with high-frequency group, in an interview with ventilator-assisted therapy at 48h by the pre-treatment (69.53± 6.59), (71.03±6.81), (23.33±4.13) decreased to 48h of (36.70±2.29), (37.68±3.61), (3.19 ±0.73); There is PaO2 made (39.42±3.58) before treatment to rise (71.40±4.35) during 48h.3. It is visibile that by comparing the inter-groups the PaO2, FiO2, OI value in conventional mechanical ventilation group during the treatment of 1h,6h,24h,48h time were lower than pre-treatment (P<0.05); PaO2 at 1h,6h,24h,48h all time points higher than pre-treatment (P<0.05). Statistical test results within the high group are consistent with the conventional mechanical ventilation group.4. By comparing the two intra-groups, there is a greater degree of decline of the normal frequency and high-frequency group PaCO2 group after treatment 1h,6h,24h. PaO2 after treatment 1h,6h rises more significantly. FiO2 after treatment 1h,6h,24h, 48h were significantly lower than the normal frequency group. OI after treatment 1h, 6h is lower than the normal frequency group. The differences between the two groups above the corresponding index at each time point were statistically significant (P <0.05). The difference between the two groups at other time points is not statistically significant (P> 0.05).5.The high-frequency group, the incidence of air leak normal frequency group respectively 1.7%,11.7%(?2= 8.29, P=0.004), two groups of chronic pulmonary disease incidence was 6.7%,16.4% respectively.(?2= 5.472, P=0.019); two of intracranial bleeding rates were 24.2%,25%(?2= 0.023, P= 0.879), the incidence of ventilator pneumonia were 13.3%,15.6%(?2= 0.262, P=0.609), pulmonary hemorrhage were 12.5%,14.1%(?2= 0.131, P=0.717).6.The high-frequency group and the normal frequency group cure rate was respectively 93.3%/84.4%(?2= 4.963, P=0.026); duration of mechanical ventilation were (5.30±1.75) d, (6.41±2.50) d (Z=-2.420, P= 0.016), duration of hospitalization were (19.57±9.30) d, (24.42±10.72) d (Z=-2.737, P=0.006).Conclusions1.Normal frequency mechanical ventilation and high-frequency oscillatory ventilation in children can significantly improve the ability of oxygenation and ventilation function for neonatal respiratory distress syndrome. These two ways of mechanical ventilation have some value in clinical treatment.2.The two ways of mechanical ventilation in the clinical treatment can cause ventilator-related complications, but due to the fewer incidences of high-frequency mechanical ventilation than normal frequency of mechanical ventilation, the cure rate is higher than normal frequency mechanical ventilation. Tip:High-frequency mechanical ventilation for NRDS is a relatively safe and effective adjuvant therapy, which has a good prospect.