Clinical Analysis Of High Frequency Oscillatory Ventilation In Treatment Of Neonatal Respiratory Distress Syndrome

Objective:To evaluate the efficacy and safety of high frequency oscillatory ventilation(HFOV) in treatment of hyaline membrane disease(HMD or NRDS) and neonatal acute respiratory distress syndrome ARDS.Method:212 cases infants from 1997.1-2007.6 with NRDS and 62cases ARDS were enrolled in the compare study. among 212 cases NRDS 129 cases with,HFOV were cure group,and 83 cases inhaling oxygen with nasal catheter,face mask,or CPAP were regarded as control group.And among 62 cases ARDS,39 cases with HFOV were cure group,and 23 cases inhaling oxygen with nasal catheter,face mask,or CPAP were regarded as control group. Investigate their difference according to blood-gas analysis,days in hospital,successful rate and complications.Results:After 24 hours and 72 hours of treatment,PaO2,PH were significant improved and PaCO2,OI were greater descended in HFOV group(P＜0.05).Successful rate was higher in HFOV group.Days in hospital and complications of heart failure,pulmonary hemorrhage and NEC were lower than control group(P＜0.05).There were no significant difference between the two groups in the incidence of intracranial hemorrhage(P＞0.05).Conclusion:HFOV is efficient and safe for treatment of NRDS and ARDS.It can rapidly improve oxygenation,decrease complication and hospitalization time.HFOV is a positive way of ventilation.