Clinical Study Of Idiopathic Interstitial Pneumonia With The Treatment Of N-Acetylcysteine Combined With Methylprednisolone

Objective: By clinical observations on the clinical manifestations?lung function?chest HRCT?blood gas analysis and inflammatory index(suc as hs-CRP)level changes of idiopathic pneumonia before and after the treatment with acetylcysteine tablets combined with methylprednisolone therapy and make a further study of the mechanism of idiopathic interstitial pneumonia with the treatment of acetylcysteine tablets combined with methylprednisolone,so as to provide a new method and reliable theoretical basis for the clinical treatment of in-depth exploration of idiopathic interstitial pneumonia.Methods: According to the criteria diagnosis of idiopathic interstitial pneumonia,we intend to choose 60 patients which are in accordance with diagnosis standards of idiopathic interstitial pneumonia from the Respiratory Department of Xiang Ya Hospital of Central South University from 2013 to 2015 as clinical observation objects.This study is a retrospective clinical study,dividing randomly them into treatment group and control group,and each group has 30 patients,Two groups of patients are given the same routine treatment of the western medicines such as oxygen,spasmolysis and asthma therapy,relieving cough and eliminating phlegm according to the illness.The control group is treated with methylprednisolone for conventional anti-inflammatory treatment for about 2 weeks while the treatment group is treated with acetylcysteine for dispelling phlegm and antioxidant on the basis of the control group for also about 2 weeks.If the two groups of patients are infected,using antibiotics similar to the treatment according to the results of drug sensitivity tests and without the use of vitamin C,Vitamin E and other anti-oxidant therapy.By observing the clinical symptoms such as the cough,breathing difficulties and shortness of breath after activities and so on? pulmonary Velco sound?chest HRCT? pulmonary function?blood gas analysis and inflammation index levels before and after treatment of the idiopathic interstitial pneumonia is to know about the effects before and after treatment.Results: 1?The two selected groups of patients with basic information and the similiar symptoms and signs,pulmonary function,chest HRCT,blood gas analysis and arthritis index such as high-sensitivity C-reactive protein(hs CRP),which are not signif-icantly different(p>0.05);?The clinical manifestations,pulmonary function,blood gas analysis,hs-CRP of the two group of patients after treatment are improved in different degrees,and the difference is statistically significant.(P<0.05).? The improvement of pulmon ary function,blood gas analysis,hs-CRP in the treatment group is better than thatin control group(P<0.05).? The positive number in chest HRCT is no significant difference before and after treatm ent(P>0.05);Conclusions:1?Acetylcysteine combined with methylprednisolone for the treatment of idiopathic interstitial pneumonia have better effects on the clinical manifestations?lung function?blood gas analysis? hs-CRP of patients than the only use of methylprednisolone in treating the idiopathic interstitial pneumonia.2? Acetylcysteine combined with methylprednisolone for the treatment of idiopathic interstitial pneumonia has some certain effects on clinical manifestations ?blood gas analysis?pulmonary function?chest HRCT especially on improving the patients clinical symptoms ?blood gas analysis?pulmonary function,but due to the lack of test cases and observations time included,therefore we need to confirm more experimental researches.