| Objective: This topic through the use of low frequency electro acupuncture on two groups of male and female spleen deficiency of the treatment of simple obesity patients,the researsh observed the changes of content of the body weight, body mass index(BMI) and body fat percentage(F%), bust, waistline, hip circumference, waist hip ratio, blood glucose(Glu),cholesterol(TC), triglyceride(TG), high density lipoprotein cholesterol(HDL), low density lipoprotein cholesterol(LDL), Insulin(Ins), and Insulin resistance Ins-Ab, leptin(leptin), adiponectin(ADPN), neuropeptide Y(NPY)of the two groups of female and male of simple obesity before and after therapy and compared the effect of weight loss of the two groups.In depth study of the difference of the weight loss effect and the possible mechanism,In order to provide a scientific basis for the clinical application of low frequency electroacupuncture treatment of male and female of simple obesity.Methods: This study included 80 patients with simple obesity, both from October 2015 to March 2014 during the outpatient department of Hebei Traditional Chinese Medicine College and the Hebei Provincial Institute of traditional Chinese medicine hospital outpatient.All patients were selected strictly according to the diagnostic criteria, inclusion criteria and exclusion criteria, in which 43 cases were female and 37 cases were male.The treatment methods of the two groups were the same.Acupoints: Yinlingquan(SP9)(double), Sanyinjiao(SP6)(double), Zusanli(ST36)(double), Fenglong(ST40)(double), Quchi(LI11)(double), Tianshu(ST25)(double),Zhongwan(CV12), Shuifen(CV9), Qihai(CV6), Guanyuan(CV4) and adipose accumulation parts of Ashi point 2 to 4 points.Operation:Patients take supine position,The needle with a diameter of 0.30~0.34 * 40~75mm needle.The body chooses one side 2~3 to the point, and the two sides are usedalternately.Acupoint after routine disinfection, Inserting needle, to get needling feeling,connecting Hua Tuo brand SDZ-II type electro acupuncture apparatus;Penetration needling method was adopted in the abdominal cavity,Zhongwan through Shuifen, Qihai through Guan yuan, and also fat accumulation point penetration needling method was adopted(right after getting needling feeling, the needle tip to the accumulation of fat,then along down penetration),then electro acupuncture Instrument(20Hz,continuous wave)was applied,for 30 min,1 times /d, 10 times for 1 course of treatment, 2days of rest between the course of treatment, continuous treatment of 2courses. Followed up for 3 months after the end of treatment.Two groups of patients before and after by assign special personnel to measure the statistical height, weight, waist circumference, hip circumference, waist to hip ratio and body fat percentage(% fat) etc. index.Simultaneous to detect the content of blood glucose(Glu), total cholesterol(TC), triglyceride(TG), high density lipoprotein cholesterol(HDL), low density lipoprotein cholesterol(LDL),Insulin(Ins), and Insulin resistance Ins-Ab, leptin(leptin), the content of adiponectin(ADPN), neuropeptide Y(NPY).The data of the two groups before and after treatment were analyzed statistically by using SPSS13.0software.Results:1 General data comparison:Through the comparison of the two groups of treatment before the age, course of disease, obesity and other data, the difference was not statistically significant(P>0.05).2 Comparison of curative effect between male and female groups:After treatment, the effective rate of male group was 32.43%, the total effective rate was 97.29%, while the female group was 11.62%, and the total effective rate was 86.04%.After the ?2 test, The efficiency of the male group was better than that of the female group(P < 0.05);Total effective rate, the difference was not statistically significant(P>0.05),But the total effective rate in the male group was significantly higher than that in the female group.Compared with the female group, after the Wilcoxon rank sum test, the difference was statisticallysignificant(P < 0.05).3 Comparison of physical indicators before and after the treatment of the male group and female group:Before treatment, two groups of patients with body weight, BMI, bust, waistline, hip circumference, waist to hip ratio and F% were significantly higher than those in normal group. The difference was statistically significant(P<0.01).Comparison within the group after treatment :two groups of patients with body weight, BMI, bust, waistline, hip circumference, waist to hip ratio and F% compared with those before treatment were significantly decreased, the difference is statistically significant(P<0.01). Comparison between groups after treatment:After treatment, the weight and BMI of the male group were significantly lower than that of the female group, and the difference was statistically significant(P<0.01). The F%, waist circumference and hip circumference of the female group was significantly lower than the male group, the difference was statistically significant(P<0.01).Comparison of two groups of chest circumference and waist hip ratio, the difference was not statistically significant(P>0.05).After treatment, compared with the normal group,the body weight, BMI, bust, waistline, hip circumference, waist to hip and F% of the male group, the difference has statistical significance(P < 0.01);There was statistical significance in female group BMI, body weight, chest circumference,waist circumference, F%, compared with the normal group(P<0.01); the difference was no statistically significant difference between normal hip(P>0.05).4 Comparison of three months of follow-up and before treatment in the male and female groups:Comparison within the group after treatment :Follow up of 3 months the patient's body weight, BMI, chest circumference, waist circumference, waist hip ratio and F% were significantly lower than before treatment, there were statistically significant differences(P<0.01).Comparison between groups after treatment: Followed up for 3 months, the body weight,body mass index(BMI) of the male group than female group the difference was statistically significant(P < 0.01); female group F%, waist circumference,hip circumference than male group follow-up th of each month, waist circumference, hip circumference decreased significantly, the difference is statistically significant(P<0.01). Comparison of two groups of chest circumference and waist hip ratio, the difference was not statistically significant(P>0.05).5 Comparison of serum lipid levels between male and female groups before and after treatment:Before treatment,the contents of TC, TG and LDL in the two groups were significantly higher than those in the normal group,while the content of HDL was significantly lower than that of the normal group, the difference was statistically significant(P<0.01); Comparison within the group after treatment : the contents of TC, TG and LDL were significantly decreased in the two groups than before treatment, while the content of HDL was significantly increased, the difference was statistically significant(P<0.05). Comparison between groups after treatment:There were no significant differences in the improvement of HDL, TG, LDL and TC between the two groups after treatment, and the difference was not statistically significant(P>0.05). After treatment, there was no significant difference in the content of LDL, TG, HDL and TC between the two groups(P > 0.05).6 Comparison of Glu, Ins, Ins-Ab and ADPN in male and female group before and after the treatment :Before treatment, the levels of ADPN, Ins,Ins-Ab and Glu in the two groups were significantly higher than those in the normal group, the difference was statistically significant(P<0.01).Comparison within the group after treatment : The content of Glu, Ins, Ins-Ab and ADPN were significantly lower than before treatment, the difference was statistically significant(P<0.01 or P< 0.05).Comparison between groups after treatment:The content of Ins and ADPN in the male group was significantly lower than that in the female group, and the difference was statistically significant(P<0.01 or P<0.05).There was no significant difference in the improvement level of Glu and Ins-Ab between the two groups(P>0.05).After treatment, the levels of Glu, ADPN, Ins and Ins-Ab in the two groups were not statistically significant(P>0.05).7 Comparison of serum levels of Leptin and NPY in the male and female groups before and after treatment:Two groups of patients before treatment the serum Leptin and NPY levels were significantly higher than the normal group,the difference was statistically significant(P<0.01). Comparison within the group after treatment :The serum levels of Leptin and NPY were significantly decreased in the two groups than before treatment, and the difference was statistically significant(P<0.01). Comparison within the group after treatment :The improvement level of NPY in male group was better than that in female group, and the difference was statistically significant(P < 0.01). The improvement of serum Leptin in female group was better than that in male group, and the difference was statistically significant(P < 0.01).The difference after treatment, serum Leptin, NPY levels of the two groups than in the normal group were not statistically significant(P>0.05)8 Comparison of adverse events rates in male and female groups:The adverse events rates of the two groups were 0%, and the difference was not statistically significant(P>0.05).Conclusion:1 Low frequency electroacupuncture can significantly reduce the male and female patients with simple obesity, body weight, BMI, bust, waistline,hip circumference, waist hip ratio(WHR) and F%.That is good for the antiobesity effect of therapy of two groups of patients were significantly reduced and the slimming effect, not only has good curative effect, but also long-term effect is good, no obvious rebound.2 Low frequency electroacupuncture could significantly reduce the male and female patients with simple obesity TC, TG, LDL content, and increase the content of HDL.It may regulate body obese patients with abnormal lipid metabolism, inhibit fat synthesis, promote fat decomposition, oxidation of heat,consumption of excess fat, so as to achieve the purpose of weight reducing.3 Low frequency electro acupuncture can significantly reduce the content of Glu, Ins, Ins-Ab and ADPN in serum of male and female simple obesity patients.The effect may be through increased islet beta cell sensitivity andsecretory function and correct the disorder in patients with obesity fatty Insulin endocrine axis; and regulation of antibody, abnormal levels of adiponectin, improve Insulin resistance, improve the utilization rate of Insulin,regulation of blood glucose and lipid metabolism, reducing food intake,increased energy consumption, so as to achieve the purpose of weight loss.4 Low frequency electro acupuncture can significantly reduce serum Leptin and NPY levels in male and female patients with simple obesity.The effect may be through the improvement of disorder in patients with obesity leptin hypothalamic NPY, prompting serum leptin through the blood brain barrier(BBB), inhibition of hypothalamic arcuate nucleus and dorsal shape nuclear npymrna expression, decrease in NPY secretion, reducing food intake,increased energy consumption, inhibit fat formation, so as to achieve the purpose of weight loss.5 There is a certain gender differences in low frequency electroacupuncture on simple obesity weight loss, the improvement effect of BMI, ADPN, Ins and NPY in male body weight was more obvious;the improvement the role of female F%, waist circumference, serum content of Leptin was more obvious.But the difference changes on chest circumference,waist hip ratio, serum Glu, TC, TG, HDL, LDL and Ins-Ab are not obvious.It also provides guidance for the clinical application of low frequency electro acupuncture therapy for the treatment of obesity in men and women.6 The clinical application of the therapy without adverse reactions, can avoid the side effects caused by western medicine, is a safe and effective treatment method.7 This experiment from the point of view of sex of low frequency electroacupuncture treatment of simple obesity attempts to make a study, and achieved certain results, but there are still some problems, such as high-frequency electro acupuncture and electroacupuncture, a waveform with different waveforms, for male and female simple obesity patients differences rema Ins to be further research and discussion. |
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