The Primary Mechanism Research About Treating The Vertebral-artery-type Cervical Spondylosis Phlegm-Dampness Stagnation With Compound BuZhongYiQiTang Formula

Introduction:Cervieal spondylosis of vertebrals artery type(CSA)is the one of the commonest type of the cervical spondylosis.And CSA is also the common and multiple dissease in middle and old ages people.The main clinical symptoms of CSA are giddiness,headache,nausea,vomiting,blurred vision,and partial eldly patients had the history of postural fall.Recently,with the changes of life style and ageing society,the morbidity of CSA is significant increasing and had younger trendcy.There are a mater of debates regarding its pathogenesis and diagnosis.The study reviewed a lot of referenee of CSA on traditional Chinese medicine(TCM)and western medicine.Accoding to TCM theory,the disease should be belonged to giddiness,headache,cervicobrachialgia and cervico brachial syndrome.After several-year clinical practicesmy supervisor found that the TCM syndrome of this disease indicase the PHLEGM-DAMPNESS Stagnation,which should be treated with the compound BuZhongYiQiTang Formula.This treatment method has great clinical efficacy for this disease.Objective:The research objective is objective to evaluate the treatment results of Compound BuZhongYiQiTang Formula releating to phlegm-dampness stagnation of CSA through clinical and experiments and study the mechanism of the formula.Methods:The 60 patients disgnosed to phlegm-dampness stagnation of CSA in our hospital are chosen to reaesrch objects from Apil.2015 to January 2016.All patients are dividied into two groups randomly,which are treatment group(30 cases,receiving the therapy with Compound BuZhongYiQiTang Formula)and control group(30 cases,receiving the orally therapy with nimodipine tablets).The courses of treatment of two groups are both four weeks.The safety indexes and curative effect indexes are both carried out in two groups.1 Safety indexes1)normal physical examination items:temperature,breath,pluse,blood pressure.All indexes are examined at pre-therapy and post-therapy.2)Blood and urine routine test: All indexes are examined at pre-therapy and post-therapy.3)ECG,liver and renal function test: All indexes are examined at pre-therapy and post-therapy.4)The observation of the possible adverse reactions.2.Curative effect indexes1)Evaluation Standard for Clinical symptoms and symptoms:All indexes are examined at pre-therapy and 1st,2nd,3rd,4th week post-therapy respectively.2)Observation for Clinicaleffects:All indexes are examined at pre-therapy and 1st,2nd,3rd,4th week post-therapy respectively.3)The indexes of transcranial Doppler(TCD): The indexes of peak blood flow velocity(Vs),end diastolic blood flow velocity(Vd),mean blood flow velocity(Vm)and blood vessel pulsation index(PI)of the bilateral vertebral artery and basilar artery are examined at pre-therapy and 4th week post-therapy.Results: 1 Safety indexes1)normal physical examination items:The indexes of the temperature,breath,pluse,blood pressure are no different between two groups at pre-therapy and 4th week pre-therapy(P>0.05).2)Blood and urine routine test: All indexes of blood and urine routine test are no different between two groups at pre-therapy and 4th week pre-therapy(P>0.05).3)ECG,liver and renal function test: All indexes of ECG,liver and renal function test are no different between two groups at pre-therapy and 4th week pre-therapy(P>0.05).4)The observation of the possible adverse reactions: The incidences of all kinds of possible adverse reactions are no different between two groups at 4th week pre-therapy(P>0.05).And no serious adverse reaction is happened.5)Overall evaluation of safty: The ratios of class one and two are no different between two groups(P>0.05).2 Curative effect indexes1)Evaluation Standard for Clinical symptoms and symptoms:The degree of the improvement of the clinical symptoms are no different between two groups at pre-therapy and 1st week pre-therapy(P>0.05).2)Observation for Clinical effects:The integrals of syndrome of Traditional Chinese Medicine are no different between two groups at pre-therapy and 1st week pre-therapy(P>0.05).3)The indexes of transcranial Doppler(TCD): The indexes of peak blood flow velocity(Vs),end diastolic blood flow velocity(Vd),mean blood flow velocity(Vm)and blood vessel pulsation index(PI)of the bilateral vertebral artery and basilar artery are no different between two groups at pre-therapy(P>0.05).But the above indexes in treatment group are higher than in control group since 2nd week pre-therapy(P<0.05).Conclusion:The clinical symptoms of patients with phlegm-dampness stagnation of CSA are improved by the therpy with the Compound BuZhongYiQiTang Formula.And the safty of this therpy is perfect and the clinical effect is time dependence.The treatment mechanism of the Compound BuZhongYiQiTang Formula is related to improving the patient's blood circulation and dilating the blood vessels.