Chronic Obstructive Pulmonary Disease Stabilization Of TCM Syndrome Distribution And Yiqi Huoxue Phiegm Side Effecy On The Treament Of Copd Airway Inflammation Of Rats Model Of Experimental Research

1 Clinical research1.1 Objective: Research on chronic obstructive pulmonary disease of the distribution regularity of syndrome.1.2 Method : Develop copd stabilization of TCM syndrome questionnaire, analysis of TCM syndrome types and clinical symptoms, age, gender, smoking, pulmonary function, the relationship between CAT score, coating on the tongue and pulse condition.1.3 Result : 136 cases of patients with chronic obstructive pulmonary disease stabilization, male, 100 people, accounting for 74% of the total, 36 people, women account for 26% of the total, 6 cases pulmonary qi deficiency syndrome, lung temper the 25 cases, lung and kidney deficiency syndrome 51 cases, lung and kidney Yin deficiency syndrome two 54 cases, the CAT rating of each card type analysis of variance(P < 0.05), pulmonary function, analysis of variance(P < 0.05).1.4 Conclusion : Chronic obstructive pulmonary disease stabilization in lungs kidney deficiency and kidney Yin deficiency of lung is, men and women clear difference incidence, associated with smoking, card type distribution associated with lung function, the CAT score.2 Experimental study2.1 Objective : Study of yiqi huoxue phlegm party mechanism for the treatment of chronic obstructive pulmonary disease airway inflammation2.2 Method : Be smoked and lipopolysaccharide manufacturing COPD rats model,randomly divided into 7 groups, namely model group, a prednisolone treatment group(western medicine group), the liquid gold treasure group(traditional group), yiqi huoxue phlegm high, medium and low dose group, the blank group, except the blank group, all give corresponding treatment for 28 days, lung function, put to death in the rat, materials, observe the lung tissue pathology, inflammation index of serum, alveolar lavage fluid, statistical analysis.2.3 Result:2.3.1 Yiqi huoxue phlegm effects on rat pulmonary functionEach rat FVC, FEV0.3, FEV0.3 / FVC variance analysis(P < 0.05), high, medium and low groups are compared, and two(P < 0.05), high dose group of FVC, FEV0.3,FEV0.3 / FVC, relatively high dose group, low dose of high dose group.2.3.2 Yiqi huoxue phlegm in rat serum IL- 8, the effect of TNF- a and CRPAnalysis of variance between groups of serum inflammatory indexes(p < 0.05), and are compared, and two differences between high, medium and low dose group(p <0.05), the greater the dose, IL- 8, TNF- a, the lower the value of CRP.2.3.3 Yiqi huoxue phlegm on rat BALF IL- 8 and the effect of TNF – aLavage inflammatory indexes between groups of cells for analysis of variance(p <0.05), and are compared, and two differences between high, medium and low dose group(p < 0.05), the greater the dose, IL- 8, the lower the TNF- a value.2.4 ConclusionYiqi huoxue phlegm can improve the rat lung function, reduce rat BALF and the level of serum TNF and IL- 8- a and CRP levels in the blood, has therapeutic effect on airway inflammation, in certain dose range, dose and curative effect is dependent on effect relationship.