Research On The TCM Syndrome-effect Relationship Of Non-alcoholic Simple Fatty Liver By Jiawei Linggui Zhugan Granules

Objective: To observe the clinical therapeutic effect of non-alcoholic simple fatty liver(NAFL)which has three common syndrome types with Jia wei Ling Gui Zhu Gan Granules,exploring the syndrome-effect relationship between them from the point of testing syndrome type with formula,and further clarifying that traditional Chinese medicine(TCM)which needed to combine differentiation of disease with dialectic in clinical applications guided prescription.Methods: According to the inclusion criteria,gathering 90 cases of nonalcoholic simple fatty liver was divided into three groups,internal retention of phlegm and dampness group,dampness heat accumulation group,phlegm and blood stasis group all had 30 cases,respectively.They took Jia wei Ling Gui Zhu Gan Granules which was infused in boiling water,one dose per day,two times,a course of 12 weeks,meantime carrying out the same basic therapy.Observing in patients with CT ratio o f liver-spleen,TCM symptom score,BMI,TC,TG,etc.SPSS17.0 with statistical analysis,to evaluate the syndrome-effect relationship between Jia wei Ling Gui Zhu Gan Granules and the three syndrome types of NAFL.Results: 1?Comparison of the overall clinical efficacy : The total effective rate of internal retention of phlegm and dampness group,dampness heat accumulation group,phlegm and blood stasis group was 67.86%,42.86%,78.57%,respectively.Two comparative analysis among the three groups,phlegm and blood stasis group was comparable with dampness heat accumulation group,internal retention of phlegm and dampness group,statistical analysis of significant differences(P<0.01,P< 0.05).The comparison between internal retention of phlegm and dampness group and dampness heat accumulation group was also significant difference(P<0.05).2 ? Comparison of CT:(1)Comparison of CT efficacy: The total effective rate of internal retention of phlegm and dampness group,dampness heat accumulation group,and phlegm and blood stasis group was 64.27%?57.14%?82.14%,respectively.The comparison between phlegm and blood stasis group and other two groups,there were significantly different(P<0.01,P<0.05).Effective between internal retention of phlegm and dampness group and dampness heat accumulation group has no significant difference(P>0.05).(2)Comparison of CT ratio change: phlegm and blood stasis group before and after treatment in CT ratio change(P<0.01),internal retention of phlegm and dampness group and dampness heat accumulation group on this aspect were all significantly different(P<0.05);the comparison between groups after treatment,phlegm and blood stasis group compared with other two groups(P<0.05),internal retention of phlegm and dampness group and dampness heat accumulation group has no significant difference(P>0.05).3?Comparison of TCM syndrome: The TCM syndrome score rate of internal retention of phlegm and dampness group,dampness heat accumulation group,phlegm and blood stasis group was 71.43%,53.57%,82.14%,respectively.Phlegm and blood stasis group compared with other two groups,there were significantly different(P<0.01,P<0.05).while,The comparison between internal retention of phlegm and dampness group and dampness heat accumulation group has no significant difference(P>0.05).Before and after treatment among three groups in syndrome score,there was significant difference(P<0.01).About the difference between groups,phlegm and blood stasis group compared with other two groups,there were significantly different(P<0.01),internal retention of phlegm and dampness group and dampness heat accumulation group has no significant difference(P>0.05).4?Comparison of blood lipids(TC?TG): The total effective rate of internal retention of phlegm and dampness group,dampness heat accumulation group,phlegm and blood stasis group was 67.88%?60.71%?85.71%,respectively.Effective between internal retention of phlegm and dampness group and dampness heat accumulation group(P>0.05).The comparison between phlegm and blood stasis group and other two groups,there were significantly different(P<0.01,P<0.05).Before and after treatment among three groups in blood lipids index,there was significant difference(P<0.01,P<0.05).5?Comparison of BMI: Before and after treatment among three groups in BMI,there was significant difference(P<0.01).6?Safety index: The safety index of three syndrome types before and after treatment had no abnormal changes;patients of three groups didn't suffer adverse events and adverse reactions.Conclusion(s): 1?The clinical effective of Jia wei Ling Gui Zhu Gan Granules on non-alcoholic simple fatty liver was obvious,it can obviously improve the patients' clinical symptoms and severity of disease,reduce blood lipids and BMI,delay the progression of disease.2?There was obviously clinical effective that Jia wei Ling Gui Zhu Gan Granules treated NAFL which had internal retention of phlegm and dampness,dampness heat accumulation,phlegm and blood stasis.phlegm and blood stasis has the best effective among the three groups.3?It's safe that Jia wei Ling Gui Zhu Gan Granules treated NAFL which had internal retention of phlegm and dampness,dampness heat accumulation,and phlegm and blood stasis.There was no adverse reactions.