Effect Of Total Saponins Of Notoginseng Total Saponin On TM,PAI-1,NO And IL-6 In Patients With Systemic Lupus Erythematosus Complicated With Atherosclerosis

Objective: Lupus erythematosus systemic(SLE)is a kind of autoimmune connective tissue disease which can cause multiple system damage,and may involve multiple target organs including the heart.Heart disease is one of the most important clinical manifestations of SLE patients,with high morbidity and mortality.Cardiac injury is currently recognized as the third largest cause of death after infection and renal failure in patients with [1].The aim of this study was to observe the changes of SLE,TM,IL-6,PAI-1,NO.Method: 90 patients with SLE from November 2014 to January 2013 were included in this study.78 patients were treated with female patients,12 male patients,aged 13~73 years,average 42.82 years old,and the duration of disease was 20 years,the shortest was 20 days.Grouping according to different research purposes:The changes of SLE,TM,PAI-1,IL-6 levels were compared with SLE,NO,C4,C3,IL-6,TM,D-dimer,PAI-1,SLE,et al.To observe the effect of total saponins from three seven patients with SLE combined with cardiovascular injury,42 patients with SLE were included in the study.Three seven total saponins of blood circulation and blood stasis drugs-injection(Wuzhou Guangxi pharmaceutical Limited by Share Ltd)the main ingredients,500 mg injection with 5% glucose injection 250 ml,once a day,intravenous drip,2 weeks for 1 courses.Serum uric acid levels,erythrocyte sedimentation rate,reactive protein,C two,C3,C4,D-,IL-6,TM,NO,PAI-1,SLE,and SLE were measured.Result:1 compared with SLE,the levels of triglyceride and cholesterol were significantly increased in patients with SLE combined with cardiovascular injury(C),and the levels of serum uric acid,serum uric acid,C3,C4 and P<0.05 were not significantly different(P>0.05).2 compared with the non combined cardiovascular injury group,the serum levels of D-two were significantly elevated in patients with combined cardiovascular injury.(rank sum test,P=0.01).3 there was no significant difference in the proportion of abnormal blood platelet count in the patients with combined cardiovascular injury group and non cardiovascular injury group.(chi square test,P=0.189).4 compared with non combined cardiovascular injury group,the serum IL-6 level and PAI-1 level in patients with combined cardiovascular injury group were significantly different,and the difference was statistically significant(P<0.05).Serum TM level was significantly different(P<0.05),and serum NO level was significantly different(P<0.05),and serum NO level was significantly decreased in patients with cardiovascular injury.5 Three seven SLE combined with cardiovascular injury group,the level of erythrocyte sedimentation rate,high sensitivity C reactive protein level,triglyceride level and cholesterol level were decreased,while the level of serum uric acid and serum uric acid level and C4,P level were not significantly different before and after treatment(P> 0.05).6 The serum levels of,PAI-1 and TM were decreased in three seven SLE combined with cardiovascular injury,and the levels of serum IL-6,and NO were decreased,and the difference was statistically significant(P<0.05).Conclusion: serum levels of triglyceride,cholesterol and D-levels in SLE patients may play a role in cardiovascular injury.Serum levels of C reactive protein,serum uric acid,serum uric acid,C4?C3,TM,NO,IL-6,PAI-1 and levels.