| Objective: Slow transit constipation(STC) is chronic, functional, primary, transit constipation. With the change of the structure of diet, accelerating pace of life and spirit of social psychological, STC has become a rising incidence disease and the main symptoms which affect the physical and mental health of people. Drug therapy, biofeedback therapy, water therapy and surgical cure are the main treatment of STC, including a laxative, promote gastrointestinal medicine, intestinal microbioecological preparation, enemas and so on. The effect of the short-term curative is satisfied, but it has high rate of relapse after drug withdrawal. If the patients use this treatment for long term, they will have drug dependence as the adverse reaction. In addition, the operative trauma is also an aspect, so postoperative side effects of this treatment cannot be avoided. The paper is based on the traditional theory of Chinese traditional medicine, taking the principle of dialectical treatment and the overall concept. Then the author discussed the method of treatment of constipation and observed liver dispersing for the treatment of the clinical efficacy of treatment of slow transit constipation. Finally the author tried to explore and seek treatment which is suitable for the safe and effective clinical constipation.Methods:1 The author chose the method of randomized controlled in this study and selected 120 cases in anorectal of Hospital of Traditional Chinese Medicine of Hebei Province. The 120 cases meet the standard of functional constipation on STC. They all belonged to the type of spleen deficiency and volunteered for this experiment with a consent form signed.2 These patients randomly divided into three groups-44 patients of group A, 37 patients of group B and 39 patients of group C. Group A used the method of liver dispersing with spleen strengthening and took Prucalopride Succinate Tablets(Xi'an-Janssen Pharmaceutical Ltd production. Approval number: H20140058). Group B used the method of liver dispersing with spleen strengthening. Group C took Prucalopride Succinate Tablets. The course of treatment is 4 weeks.3 After the treatment of 3 months, the author made interviews of all these patients. Analyzing by the statistical software, the ages, genders, medical histories and symptoms of the treatment show no statistical difference(P<0.05) that is to say they all had comparability. After the end of treatment, the author analyzed and evaluated the symptoms integral, the total integral, symptom curative effect and follow-up of relapse, security index in pretheraphy and post-treatment.4 The data is all using SPSS 21.0 statistical software to analyze and enumeration data is using mean ± standard deviation( SX ±). The measurement data meets the normality of variance homogeneity using t test, does not conform to the normality and homogeneity of variance with rank and inspection. And P < 0.05 means it has statistical significance.Results:1 After the treatment, the total effective rate of group A was 93.2%, including 13 cases of recovery, 14 cases of marked effectiveness, 14 cases of effectiveness, 3 cases of invalid; the total effective rate of group B was 81.2%, including 10 cases of recovery, 12 cases of marked effectiveness, 8 cases of effectiveness, 7 cases of invalid; the total effective rate of group C was 74.4%, including 3 cases of recovery, 9 cases of marked effectiveness, 17 cases of effectiveness, 10 cases of invalid. The comparison of statistical significant(P < 0.05) in three groups are: there was no statistical significant between group A and group B(P>0.05); there was statistical significant between group A and group C. So were group B and group C(P<0.05). Symptomatic efficacy of group A was better than that of group C, group B was better than that of group C, group A and group B compared with no difference.2 The drugs of three groups can relieve constipation symptoms and clinical disease effectively. Group B was better than that of group C(P < 0.05) in two aspects-bowel traits and defecation time. Group A was better than that of group C(P < 0.05) in improving abdominal distension. But in improving the difficult defecation, fall bilge feeling and frequency, three groups have no statistical significant(P > 0.05).3 After the treatment, group A was better than that of group C(P < 0.05) in improving clinical symptoms integral. Group B was better than that of group C(P < 0.05). There was no statistical significant between group A and group B.4 During the time of patients taking drugs, some of them had a headache-2 cases in group A, 3 cases in group C, and no case in Group B.5 At the end of the three-months course, the recurrence rate in group A is 11.1%, 13.6% in group B and 33.3% in group C. There was no statistical significant among these three groups.Conclusions:1 Liver dispersing with spleen strengthening and Prucalopride Succinate Tablets both can improve the patients with slow transit constipation clinical symptoms.2 In the aspects of transit constipation defecate character and defecation time, liver dispersing with spleen strengthening is better than Prucalopride Succinate Tablets. In the aspect of improving abdominal distension, using the two drugs in combination is better than only using Prucalopride Succinate Tablets.3 Liver dispersing with spleen strengthening in the treatment of slow transit constipation had a curative effect based on surveys. The long-term curative effect of it was satisfied. |
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