Comparative Study Of Cognitive Function In Schizophrenia First Degree Relatives And First-episode Schizophrenic Patients

BackgroundSchizophrenia is a common severe mental illness and a group of unknown etiology,pathogenesis and mechanism of schizophrenia,but at present,in the study of family genetic,molecular genetic aspects were found in this kind of disease has a genetic characteristics,genetic factors in the pathogenesis of schizophrenia how to play a role,it is inconclusive;cognitive function in patients with schizophrenia of the damage caused by its social function recovery difficulty is the bottleneck problem in the process of clinical treatment discussed characteristics of cognitive impairment of patients with schizophrenia;the comprehensive treatment methods to help patients with the disease restore cognitive has very important practical significance.Objective1.The difference of cognitive function among the normal control group,the group of first episode patients with schizophrenia and their first-degree relatives;2.The influence of family history of psychosis on cognitive function in first-episode schizophrenic patients;3.The difference of cognitive function before and after treatment in first-episode schizophrenic patients with atypical antipsychotic,the first group in this study were treated with risperidone;through the above reseach,can help find the inherent characteristics of patients and their family members in addition to genetic heterogeneity,thus for the incidence of the disease before doing some effective intervention.MethodsThe research is conducted as following: 60 members are chosen respectively from the groups mentioned above and three sample groups are formed including patient group,relatives group and the normal group.These three groups are researched in this study.Symptom assessment is completed by ten psychiatric doctors after the standardized training.Cognitive function assessment tools adopt the standardization of measuring tool of schizophrenia cognitive curative effect evaluation: Schizophrenia MATRICS consensus cognitive battery(MCCB),Contains six tests,including the trail making test,Stroop color word test and others.The assessment is completed by two trained associate chief physicians,and whole data results of this study are dealed with SPSS 24.00 software.Results1.Schizophrenia neuropsychological test scores between patient group and control group are quite different which means the research has statistical significance(P<0.01);the scores between relative group and the control group are also very different in the tests of word line,symbol encoding,grades HVLT-R and the Stroop color word,color vocabularieswhich is also proved to be statistically significant(P<0.01).In the tests of Stroop color vocabulary test as well as the continuous performance(CPT),it scores differently between the relative group and the control group which is statistically meaningful(P<0.05),the research results are between the ones of patient group and control group.2.The scores between patient groups with and without positive family history are also with great differences in the respects of the symbol encoding,HVLT-R(total scores,T3),CPT-IP(total scores,2D),Stroop color vocabulary.It is also proved to be with statistical significance(P<0.01)3.In the neuropsychological test,the scores of patients with first-episode schizophrenia before and after treatment in the HVLT-R and BVMT-R are significantly different and meaningful in statistics(P<0.01);the different PANSS scores before and after the treatment lead to the same conclusion: it is meaningful in statistics(P<0.01).Conclusion1.Cognitive impairment is prevalent in first-episode schizophrenia.2.Processing speed,attention to alertness,speech memory and other areas of cognitive deficits exist not only in the first episode of schizophrenia,but also in their first-degree relatives.3.As for the first schizophrenic patients with positive family history,there are more obvious defects in the attention to alert,word learning and memory,working memory and other areas.4.The cognitive function can be improved after the first episode of schizophrenia patients are treated,their recovery of memory,the speed of information-processing and attention alert is more obvious.