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Clinical Study On Erxian Decoction For Controlling Of Menopausal Symptoms Caused By GnRH-a Treatment For Endometriosis After Laparoscopic Surgery

Posted on:2016-01-13Degree:MasterType:Thesis
Country:ChinaCandidate:J P HuangFull Text:PDF
GTID:2334330461981593Subject:Traditional Chinese medicine
Abstract/Summary:PDF Full Text Request
ObjectiveThe aim of the study is to investigate the clinical efficacy and safety of Erxian Decoction treating menopausal symptoms caused by GnRH-a treatment for endometriosis after laparoscopic surgery,which is looking forward to avoid the side effect of hormone and provide a kind of effective traditional Chinese medicine treatment.MethodsThe study was a simple randomized controlled clinical trials.Selecting the patients from September,2013 to March,2015 in Guangdong Provincial TCM hospital,who underwent the menopausal symptoms caused by GnRH-a treatment for endometriosis after laparoscopic surgery,such as hot flashes sweating,agitation,etc.The patients were randomly divided into 2 groups:treated group and control group.The treated group was treated with Erxian Decoction granules,and the control one was treated with add-back therapy(Prognova 0.5mg+Dydrogesterone 10mg),respectively for 1 month.Before and after treatment,we measured and recorded some index,including total score of Kupperman menopause and single item score of it,TCM syndrome Rating Scale score,and the follicle-stimulating hormone(FSH),estradiol(E2)levels.Results1.Total effective rate in the treated group and the control group overall curative effect quite.There was no significant difference between the two groups in this part(P>0.05).2.Both of the two groups could significantly decrease the KMI score?the hot flaehes sweating of the patients than it before treatment(P<0.05).The difference of two groups after treatment is statistically significant(P<0.05),indicating that the treatment group decreased Kupperman score and improve the hot flashes sweating,psychiatric symptoms significantly compared to the control group.3.Both of the two groups can decrease the menopausal syndrome scale score.In the treatment group and control group menopausal syndrome scale scores decreased significantly compared with prior treatment.The difference was statistically significant(P<0.05).Through the comparison between the two groups,the difference was statistically significant(P<0.05).4.Both of the two groups can improve lower estrogen levels,the difference was statistically significant(P<0.05).Between the two groups after treatment differences were not statistically significant(P>0.05).Conclusion1.Erxian Decoction and hormone add back all can improve the menopausal symptoms caused by GnRH-a treatment for endometriosis after laparoscopic surgery,Erxian Decoction's effect is more significant.2.In the aspect of improving the level of E2,both of the two groups are effctive.But the effect of hormone add back is better than Erxian Decoction.
Keywords/Search Tags:Erxian Decoction, Endometriosis, Add back therapy, GnRH-a
PDF Full Text Request
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