Study On Pharmacokinetics Of Boluohui Powder And Bopu Powder In Pigs

With anti-inflammatory,anti-tumor,growth-promoting effect and so on,Macleaya cordata?Willd.?is widely used in the field of agriculture,animal husbandry etc al.Although there are some reports about pharmacokinetics of SA,CHE,PRO,ALL,systematic and in-depth researches are exile,and yet those with guidance to clinic are much less.In order to provide better guidance to clinic,work in the tests are as follows:1.The pharmacokinetic tests in pigs of Bopu powder was conducted with Oral and rectal administration by referencing the clinical dosage.2.The pharmacokinetic tests in pigs of Boluohui powder was conducted with Oral and rectal administration by referencing the clinical dosage.3.The pharmacokinetic parameters of DHSA which is the metabolite of SA were studied.The results showed that there is no blood concentration of drug measured in pigs by oral administration.By rectal administration,the pharmacokinetic parameters of SA are as follows:T_maxax is 0.1670h,C_maxax is 8.3850?g/L,AUC_?0-t?is 6.3097h·?g/L,AUC_?0-??is 7.4706h·?g/L,MRT_?0-t?is 0.8405 h,MRT_?0-??is 1.1720 h,t_1/2 is 0.6751 h,and CL is 8.031 L/h/kg.While the pharmacokinetic parameters of CHE are as follows:T_max is 0.3300 h,C_maxax is10.6900?g/L,AUC_?0-t?is 16.0234 h·?g/L,MRT_?0-t?is 1.0168 h,MRT_?0-??is 1.2307 h,t_1/2/2 is0.5635 h,and CL is 3.395 L/h/kg.The pharmacokinetic parameters of DHSA are as follows:T_masas is 0.3300 h,C_maxis 0.3500?g/L,AUC_?0-t?is 0.3486 h·?g/L,MRT_?0-t?is 0.8614 h,MRT_?0-??is 3.6959 h,t_1/2 is 2.4009 h,and CL is 5.319 L/h/kg.The results of this test prompts that the absorption effect of rectal administration is better than that oral administration in the case of the same dosage.The absorption and metabolism speeds of SA are faster than those of DHSA.SA can stay in the body only for about 2 hours,and then was eliminated,while DHSA can stay in the body for a longer time.The retention time and the apparent distribution volume?V_d?of DHSA are bigger than those of SA,and the results indicate that SA stays in the body of pig mainly in the form of its metabolites—DHSA and stay for a long time in the body of pig.