Research On Key Technology Of Sensor In Thromboelastography

The thrombelastography(TEG)is an instrument that recording time-varying changes of the blood coagulation intensity during the process of plasminogen activation and coagulation.By plotting a curve that depicting time-varying changes of the blood coagulation intensity and analyzing relevant parameters that derived from the above curve,the TEG is able to acquire changes of the viscoelasticity of blood coagulation,so it reflects the influence of relevant parameters which participating in blood clotting on the process of blood clot.With the increasingly improvement of the technology and medical technique,the importance of the detection of blood coagulation function in human body is significant especially on the detection of hemorrhagic disease,the detection of thrombotic diseases,the judgment of hemostatic function before operation,the detection of clinical drug use and the detection of disseminated intravascular coagulation.At present,the common method applied in the clinical detection of blood coagulation function is the test of four routine blood coagulation indexes.However,the above test can only detect at a single time point or a period of the process of the blood coagulation,thus the content of the test is less.Comparatively,the detection range of the TEG is much larger and the TEG could invite better reflection of the process of blood coagulation,thereby the TEG has better reference value in the clinical detection of blood coagulation.Based on the working principle of TEG,current TEG is made by inductance method.The limitation of this method is that nonlinear indexes measured at circumferential direction is much larger.The purpose of this subject is finding a way of measuring the degree of angle to achieve the measurement of viscoelasticity of blood coagulation.The angular transducer designed by this article has the characteristics of good linearity,repeatability,structure and so on,which can make up for the deficiency of the inductance method that measuring through circumferential direction.The angular transducer proposed by this subject is based on the principal of non-contact electromagnetic induction which analyzes the rotator's angular change in the framework of Sensor Networks.This thesis carefully analyzed the non-contact electromagnetic induction coupling system of the angular transducer and designed thehardware and the software part of the angular transducer.Also,this paper analyzed the major circuit of the hardware part and designed the mechanical structure of the key measuring device of TEG.In order to testify the performance of the designed angular transducer,an angle sensor experimental platform has been built.Besides,according to the design of mechanical structure of the measuring device of TEG,measuring device has been built.The operational angle of the TEG is stimulated by the experimental platform of the angular transducer.By analyzing the data measured from experiments,the results show that the linearity,hysteresis and repeatability of the angular transducer designed by this thesis is excellent and its measurement accuracy error is ±1.5%.The angular transducer is able to measure tiny angles and it is sufficient to satisfy the measurement requirement of operational angle of TEG.