The Design Of Implantable Glucose Measurement System For Animal Experiments

Objective:diabetes is one of the major disease challenges facing the 21st century human, it brings to the patients pain also brings heavy burden on society. Blood glucose concentration measurement is very important in the diabetes control and related medical research. Currently, blood glucose measurement was carried out on the experimental animals by making a small cut on the animal and squeezing out the blood sample. But this operation will bring pain, cause stress hyperglycemia and affect the accuracy of measurement. And it is easily to cause infection after the operation.Content:in order to solve this problem, this paper designed a kind of implantable wireless blood glucose measurement system. The system is divided into the implant and the receiver. Through surgical operation, the implant will be embedded in experimental animals. It will measure blood glucose and body temperature. After data processing, the results will be wireless transmission to the receiver. This article focuses on the design of implant, including the design of blood glucose measurement, temperature measurement and low power consumption of the Bluetooth radio communication. The generic Bluetooth receiver will be used for receiving.Methods:this article analyzes the functional needs and divides the system structure as blood glucose measurement module, temperature measurement module, RF transmission module and power management module. The electrochemical sensor based on glucose oxidase enzyme is selected for glucose concentration measurement. Temperature is measured by using thermistor measuring. Measurement results will be calibrated, averaged and sent to the receiver for storage and display. According to the requirements of the Bluetooth protocol stack’s requirement, system software were coded. Implantable prototypes were implemented and tested.Conclusion:The prototypes were tested for blood glucose measurement, temperature measurement, RF communications and power consumption. Test results confirmed that the prototypes meet the design requirements. This design can be applied to experimental animals.