Study On Enrichment And Edulcoration System Of VOCs Of Lung Cancer Gas Markers

Currently, lung cancer is one of the highest incidence and the highest mortalityrates of malignant disease of human malignancies.China is expected to reach about1000000of lung cancer patients, and the number of patients will be ranked first in theworld by2025.The current clinical application in lung cancer detection means more orless harmful to human, and the detection efficiency is not high.Looking for a fast,secure, inexpensive, and easy to promote detection method has important practicalsignificance. Breath diagnosis is convenient, safe and non-invasive, accompanied bytrace VOCs detection technology is developing rapidly,breath detection technology isexpected to become the most effective method for the early lung cancer detectiontechnology.As complex composition of the breath VOCs, concentration basically is between10-12mol/L to10-9mol/L, and there are many confounding factors to the detection, theenrichment and edulcoration of the exhaled gas is the key for the VOCs late detection.Based on some substances with the principle of adsorption-desorption of some gas onspecific, we designed an enrichment and edulcoration system of lung cancer markerVOCs.In this paper, introduced the related basic theories,design ideas, system buildingprocess, device test results, etc., the specific research work can be expressed as follows:①S elect method: through the analysis of the target gas in common, based on thevisualization porphyrin array sensor detection system of our research group, we selectthe adsorption-thermal desorption method applied to the purification of the target gas,and ultimately determined the use of mixed adsorbent for the enrichment of targetVOCs.②Design instrument: according to the selected experimental methods andmaterials, we designed a targeted multifunctional thermal desorption device, whichcombined with the associated hardware circuit design and software programming canrealize the activation, adsorption and thermal desorption in one. It fits well with theexperiment requirements of the system.③Explore conditions: we designed two calculation program of preparation ofstandard methods and determined the optimal experimental conditions with a largenumber of orthogonal experiments④Improve system: according to the experiment results and the improvement of experiment requirement, we adjusted the installation of experiment equipment andimproved the corresponding hardware circuits and software programming with the gaspath designed by the other student of our research group.After lots of experiments withthe GC and the visualization porphyrin array sensor detection system, we adjusted theexperimental process and the related technical indicators gradually.We finally obtained atemperature curve of controlled well,and better concentration and purification effect,which verified the design effectiveness.