Magnetic Resonance Spectroscopy Study Of Thalamus In Parkinson’s Disease-related Pain

Objective:To discuss the relationship between Parkinson’s disease-related pain and Parkinson’s disease course、H-Y grade.And analysis the metabolism change of thalamus in Parkinson’s disease-related pain.More understanding of Parkinson’s disease and its associated pain.Methods: Collect the information and clinical date of Parkinson’s patients. Using magnetic resonance spectroscopy to detect the metabolites content in bilateral thalamus of all the Parkinson’s patients.Use SPSS software to analyze the ratio changes of the metabolites content.Results:The proportion of the male and female was 1:1, mean age was 63.80±11.73 years,mean PD duration was 4.70±2.62 years, mean H-Y grade was 2.80 in Parkinson’s patients with pain.In Parkinson’s patients without pain, the proportion of the male and female was 1:1.5, mean age was 64.10±7.52 years,mean PD duration was 1.18±1.27 years, mean H-Y grade was1.55.The ratio of NAA/Cr,Cho/Cr,NAA/Chowere 1.71±0.08, 1.16±0.09, 1.49±0.12 in patients with pain. The ratio of NAA/Cr,Cho/Cr,NAA/Cho were1.87±0.18,1.05±0.13,1.80±0.23 in patients without pain. The difference was statistically significant(P<0.05).Conclusion:1. Parkinson’s disease-related pain occurs approximately in the course of five years.2.Parkinson’s disease-related pain is more common in advanced Parkinson’s patients.3.The thalamus neurons were impaired and with cell proliferation in Parkinson’s patients with pain, suggesting that the function of thalamus was imbalanced.