| Objective:To investigate the metabolite alteration in putamen in Patients with Parkinson’s disease and explore the value of PD dignosis and assessment of PD duration and anti-PD drug efficacy.Methods:32patients with Parkinson’s disease and15age-and gender-matched healthy controls were included in this study, all patients were rated on the UPDRS and Hoehn&Yahr scale,All subjects were spected by the single-voxel1H-MRS with15mmx15mmx15mm voxel in the bilateral putamen.Then the software attached to the equipments automatically identifies and calculates N-acetylaspartate/creatine (NAA/Cr), choline/creatine (Cho/Cr) and N-acetylaspartate/choline (NAA/Cho).Results:The ratio of NAA/Cr of the putamen is significant different between the sick side and the other side of the asymmetrical patients with PD,the ratio of NAA/Cr in the other side reduced significantly compared to the sick side and the controls. However no other changes of NAA/Cr, Cho/Cr and NAA/Cho have been detected between the patients and the controls. Neither have the relationship between the scores of UPDRS and the1H-MRS alteration nor the metabolite changes can assess anti-PD drug efficacy.Conclusion:The proton magnetic resonance spectroscopy is a valuable tool to detect the metabolic changes in patients with Parkinson’s disease. The degeneration of dopamine neurons can be discovered in putamen in the less sick side in PD. We can not infer that1H-MRS can evaluate the PD duration and the anti-PD drug efficacy. |
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