| Objective:Cerebrovascular disease is one of the main causes of death, and most of the occurrence of cerebrovascular disease are associated with carotid artery, carotid artery stenosis caused by carotid atherosclerotic plaque formation and cerebral artery embolism caused by carotid atherosclerotic plaque shedding is the main cause of cerebral ischemia. To observe the correlation between the level of soluble lectin like oxidized low density lipoprotein receptor 1(s LOX-1) and its related serum marker levels and serum Cystatin C(Cyst-C) and carotid atherosclerotic plaque formation, provide targets for clinical prevention. Method:Patients with acute cerebral infarction from April 2015 to October 2015 in Affiliated Hospital of Chengde Medical College as the research object, a total of 161 patients(mean age 58.9±8.153 years old, male 99 cases, female 62 cases). Each case was inspected by experienced physicians using the portable sonosite ultrasound system with M-Turbo complete carotid ultrasonography, according with or without carotid plaques were divided into normal carotid artery group(44 cases) and carotid artery plaque group(117 cases), with calculating carotid atherosclerotic plaque index.All of the subjects were detected Cyst-C, hs-C reactive protein, total bilirubin(TBIL),direct bilirubin(TBIL), total cholesterol(TCH),triglyceride(TG), high density lipoprotein(HDL), low density lipoprotein(LDL).Determination of s LOX-1 and MMP-9 in the samples using a double antibody sandwich method. Analysis using SPSS19.0 statistical software. The measurement data was demonstrated by mean and standard deviation( x ±s), the two groups were compared using two sample t test. Count data was demonstrated by the number of case and rate(n %),the two groups were compared by theχ2 test. Draw scatter diagram, correlation analysis using Pearson. ROC curve to evaluates the diagnostic value of markers for carotid atherosclerosis plaque. The Logistic regression analysis the risk factors of carotid plaque formation. When P<0.05,the difference was statistically significant. Results:The age and the proportion of male patients of the carotid artery plaque group was higher than that of normal carotid artery group(P<0.05); and there were not significant difference between the two group in past history of hypertension, diabetes and smoking(P>0.05). The level of serum TG in normal carotid group is lower than that in the carotid artery plaque group(P<0.05); There were no significant difference between the two groups of the levels of serum HCT, HDL and LDL(P>0.05).The level of serum s LOX-1, MMP-9, hs-CRP and Cys-C in carotid plaque group were significantly higher than that in normal carotid artery group(P<0.05); The level of serum TBIL level in carotid artery plaque group was lower than that in normal carotid artery group(P<0.05), but there was no difference in the levels of serum DBIL in the two groups(P>0.05); According to the ROC curve,the level of Cyst-C was best to diagnostic the formation of carotid plaque. Logistic regression analysis showed that male gender,high levels of s LOX-1,MMP-9,hs-CRP, Cyst-C were risk factors for carotid atherosclerotic plaque formation, and the high level of TBIL is a protective factor.Serum TBIL levels were negatively related with carotid atherosclerotic plaque index(r =-0.309, P<0.05), and the levels of serum s LOX-1,MMP-9,Cyst-C were positively related to the index of carotid atherosclerotic plaque(r = 0.583,r = 0.292,r = 0.184, P<0.05). There was no relationship between the levels of serum hs-CRP and carotid atherosclerotic plaque index(P>0.05). The level of serum s LOX-1 was negatively correlated with the levels of serum TBIL(r =-0.159, P<0.05), and positively correlated with the levels of serum MMP-9 and hs-CRP.(r = 0.539,r = 0.297, P<0.05). Conclusion:sLOX-1, MMP-9, hs-CRP, TBIL is closely related to the carotid atherosclerotic plaque formation.The high levels of s LOX-1, MMP-9, hs-CRP, Cyst-C were risk factors for carotid atherosclerotic plaque formation, and the high level of TBIL is a protective factor. The levels of serum s LOX-1, MMP-9 and Cyst-C can reflect the severity of carotid atherosclerotic plaque. High levels of Cyst-C may indicate the formation of carotid artery atherosclerotic plaque, and the level of Cyst-C has higher diagnostic value in diagnosing carotid atherosclerotic plaque formation. |
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