Clinical Observation On Treatment Of PCOS Caused Sterility By Combined Clomiphene Citrate And Bushenhuayufang

Objective: To assess the curative effect and safety index of Bushenhuayufang, to further analyze its mechanism, therefore to provide clinical evidence for TCM in treating PCOS by observing Bushenhuayufang combined with CC in treating PCOS-induced infertility patients.Methods: Seventy patients were allocated to the treatment group and the control group according to randomized and controlled method. 35 cases each group, the treatment group took Bushenhuayufang combined with CC, and the control group CC, both groups were treated for three menstrual cycles, clinical manifestation, basal body temperature(BBT), body mass index(BMI), serum hormone and the level of TNF-α were observed and recorded, the thickness of endometrium, ovary volume, ovulation and fertilization were detected by ultrasonic method, the indexes before and after treating in both groups were compared and statistically analyzed with SPSS17.0 software.Results: 1. The comparison of total effective rates: total effective rate of the treatment group is 85.29%, superior to 66.67% of the control group significantly(P<0.05).2. Thickness of endometrium: the treatment group is superior to the control group notably in the thickness of endometrium at hCG date(P<0.05).3. Ovulation and fertilization rates: Ovulation rate of the treatment group is 75.28%,higher than 60.87% of the control group remarkably(P<0.05); fertilization rate of the treatment group is 38.24%, higher than 18.18% of the control group, the fertilization rate of the treatment group is 2.1 times of the control group, but there is no statistical meaning in the comparison of the differences between both groups(P>0.05).4. The levels of serum hormone: The levels of LH, T, LH/FSH of the treatment group after treating decrease compared with before treating, the levels of E2 improve notably(P<0.05); the levels of LH, LH/FSH in the control group after treating lower compared with before treating evidently(P<0.05), the levels of E2, T and FSH change insignificantly(P>0.05); the levels of LH and T of the treatment group after treating decrease compared with the control group significantly, the levels of E2 improve evidently(P<0.05).5. The level of TNF-α: the levels of TNF-α after treating decrease clearly compared with before treating in both groups(P<0.05); the levels of TNF-α of the treatment group are lowerthan these of the control group(P<0.05).6. TCM symptom integrals: TCM symptom integrals of both groups improve(P<0.05),the color of the menses, menstrual period, dysmenorrhea, exhausted, vertigo and tinnitus,soreness and weakness of the waist and the knees, frequent urination at night and the defecation of the treatment group improve notably compared with before treating(P<0.05);the treatment group is superior to the control group significantly in the menstrual volume, the color of the menses, the nature of menses, dysmenorrhea, exhausted, vertigo and tinnitus,soreness and weakness of the waist and the knees notably(P<0.05).Conclusion: Curative effects of bushenhuayufang combined with CC are superior to CC only in treating PCOS-induced infertility patients, and it could relieve clinical symptoms,regulate internal secretion, increase the thickness of endometrium and receptivity, and decrease the level of TNF-α to improve micro-environment of the womb, therefore, to raise ovulation rate and fertilization rate, which could be spread in clinic since it shows definite effects.