A Randomized Controlled Clinical Trial By The Treatment Of Quhan Zhufeng Mixture And Guci Paste To Mild Or Moderate Patellofemoral Osteoarthritis

Objective: This topic plans by prospective randomized controlled clinical study with mild to moderate osteoarthritis of the patellofemoral joint short-term efficacy of Quhan Zhufeng mixture joint Guci paste treatment,for the establishment of Chinese medicine gradient regeneration treatment of patellofemoral osteoarthritis series of new technologies, new methods, technical quality evaluation system to provide clinical basis. Methods: A total of 60 cases of type wind musculoskeletal joints in patients with unilateral patellofemoral osteoarthritis, cases from January 2015 to September 2015, the Chinese medicine hospital of Gansu Provincial articular bone two outpatient and inpatient. Research methods prospective randomized, patients were randomly divided into two groups: the experimental group(Quhan Zhufeng mixture joint Guci paste)and control group(Sodium hyaluronate), 30 in each group. Patients in each group, starting from the date of enrollment, In the experimental group were treated with Quhan Zhufeng mixture and Guci paste, the control group were treated with intra-articular injection of sodium hyaluronate. Two groups of patients were performed in addition to the corresponding treatment, are also enjoin during treatment to avoid climbing, squat knees and other weight-bearing exercise 30 °-60 °, the treatment period was 4 weeks. Two groups of patients before treatment, respectively, to complete the course of treatment all week 0 after 6 weeks and 12 weeks of follow-up and clinical safety evaluation. Patients timing once a week telephone follow-up, and the adoption of the quantitative criteria to quantify rates of the two groups of patients with pain, signs of improvement in checking the degree of change in the patellofemoral joint cartilage ultrasound imaging, and asked in detail about whether to adverse events during the treatment of patients reaction, and the data were statistically analyzed. Results:(1) In this study, a total of 60 patients, treatment and follow-up are completed on time, in full with no loss, loss of follow-up; general information on age, sex, body mass index of the two groups were no significant difference(P> 0.05); Two groups of patients before treatment VAS score, TCM symptom classification quantitative score, WOMAC score, US ultrasound grading data of cartilage injury were not significantly different(P> 0.05);(2) After completion of the treatment of pain in patients with symptoms of the two groups were significantly improved after treatment groups were compared with the data in the pre-treatment comparison group was statistically significant(P <O.05); VAS score in the experimental group was significantly lower than the control group The difference was statistically significant(P <0.05);(3)After completion of the treatment groups quantitative score of TCM clinical symptoms were significantly improved, two groups of patients after treatment compared with the pre-treatment, comparative data was statistically significant(P <0.05); the experimental group was higher treatment efficiency, the difference was statistically significant(P <0.05);(4) After treatment completion WOMAC scores improved compared with before treatment, after treatment in the test group by comparing the differences were statistically significant(P <0.05); experimental group WOMAC score lower than the control group, the test the difference was statistically significant(P <0.05);(5) After treatment is completed before cartilage damage US rates than before treatment improved; the group before and after treatment by comparison test differences were statistically significant(P <0.05); experimental group cartilage damage US scores improved compared with the control group was not significant, the test showed no significant difference(P> 0.05); two groups of patients before and after treatment to improve the synovial thickness was not significant, the test showed no significant difference(P> 0.05);(6) groups had no significant adverse reactions, the experimental group, 5 patients had local pigmentation; two groups of patients before and after treatment ALT, AST, CREA, BUN four indicators in the comparison group, the test showed no significant difference(P> 0.05). Conclusion:(1) The Quhan Zhufeng mixture joint Guci paste effective for mild to moderate musculoskeletal type patellofemoral osteoarthritis pain patients mitigation, treatment of TCM clinical symptoms and improve function of the patellofemoral joint, promote cartilage repair have a better effect;(2) The Quhan Zhufeng mixture joint Guci paste treatment of mild to moderate musculoskeletal type patellofemoral osteoarthritis patients is safe and effective;(3) The Quhan Zhufeng mixture joint Guci paste treatment for musculoskeletal type of mild to moderate osteoarthritis of the patellofemoral joint effect sodium hyaluronate, and relatively inexpensive, with simple and inexpensive test features.