| Objective:Validation yishenhuoxuefang of the joint nim horizon treatment of kidney deficiency and blood stasis type of vascular cognitive dysfunction without dementia clinical efficacy and safety。Methods:Relevant standards, according to the sample estimate and on the basis of test in October 2013 to December 2015 in the second affiliated hospital of shanxi medical university regions and the third affiliated hospital of shanxi institute of encephalopathy of the patients with cognitive dysfunction, and will conform to the standards of Chinese and western medicine diagnosis of dementia type 60 patients with vascular cognitive dysfunction, according to the principle of randomized, controlled, the average is divided into the treatment group and control group, 30 cases in each group.Control group: in patients with control the original basic diseases such as heart disease, high blood pressure,diabetes, etc, on the basis of oral bayer pharmaceutical co.LTD. Production of nim to plain radiographs(H20003010) approved by the state, give 30 mg/time, 3 times/day treatment, a course of 4 weeks, a total of 3 period of treatment.Treatment group: basic drugs the same as the control basis for disease medication, taking nim horizon at the same time take a kidney invigorate the party(1 / day, once in the morning and night), 4weeks for a period of treatment, a total of 3 period of treatment, prescriptions for mountain cornus 15 g, huang jing 15 g, a fairy spleen 10 g, 12 g stone calamus, polygala15 g, 10 g, red sage root rhodiola 15 g.The control group and treatment group both before and after treatment. 4, 8 and 12 weeks in Montreal cognitive assessment Mo CA(Beijing)and TCM syndrome integral to improve the effect of cognitive dysfunction and evaluate the relevant TCM symptoms improve。Results:1.The test before the start of the treatment group and control group patients gender、agec、ourse、Montreal cognitive assessment scale(MoCA) and TCM syndrome integral comparison, there were no significant differences(P>0.05), can be thought of as the treatment group and control group in the baseline situation, comparable。2. The test after the start of the treatment group the Montreal cognitive assessment scale(Mo CA) 4、8 and 12 weeks scores improved compared with before treatment, and have significant difference(P<0.01), while the control group after treatment Mo CA scale score higher than 4 weeks before the treatment, but no significant difference(P= 0.083), 8and 12 weeks of Mo CA rating scale increased compared with before treatment, and there are significant differences(P<0.01).12 weeks after treatment the treatment group is higher than the control group at the same time Mo CA rating scale, and has a statistically significant difference(P<0.01).After all treatment kidney invigorate the party and nim horizon western medicine combined with western medicine alone, nim horizon both can improve the Mo CA scores of patients, and use Chinese and western medicine combined application of nim horizon in improve cognitive function in patients with more advantages.At the same time the treatment group of TCM syndrome integral 4、8 and 12 weeks scores compared with before treatment were reduced, and have significant difference(P< 0.01), the control group 4、8 and 12 weeks of TCM syndrome integral are lower than before the treatment, also had significant difference(P<0.01).At the same time12 weeks of treatment group is lower than the control group after treatment of TCM syndrome integral, with statistically significant differences(P<0.01).Results show that after the full course, Chinese and western medicine combined with western medicine alone,nim horizon both can reduce patients’ TCM syndrome integral, and the combined use of Chinese and western medicine alone nim relatively horizon in symptoms improve cognitive function in patients with an edge。3. The outcome: test after the end of the treatment group total effective rate was90.00%;And the control group total effective rate was 76.67%, total effective rate oftreatment group is higher than the control group, compared with significant difference(rank and inspection, P<0. 05)。4. Safety decision: during the clinical observation test two groups of patients with no serious obvious adverse reaction occurred.Statistical treatment group and control group before and after the whole test ALT, AST and Cr values, each value did not see obvious difference(P>0.05).Statistical results show that the treatment group and control group of drug use in the short term effects on kidney function in patients with no serious, have a certain security。Conclusion:Yishenhuoxuefang with nim horizon can effectively improve the treatment of patients with cognitive function, and in improving patients with various accompanying symptoms is superior to western medicine alone nim horizon。... |
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