Study On The Prevention Of Urinary Stone With The Use Of Vinegar In Rats

Objective:By applying vinegar paste feeding rats with urinary stones, renal tissue pathology was observed and concentration of oxalic acid and calcium levels were measured to observe the preventive effect of acetic acid on urinary calculi and further explore the mechanism. Methods:Healthy Wister rats of appropriate weight were randomly divided into groups, blank group, 1% ethylene glycol + 2% ammonium chloride Stone-induced fluid mo deling group, 30 g / 100 ml high dose of vinegar cream + 1% ethylene glycol + 2%ammonium chloride stone-induced liquid group, 10 g / 100 ml low dose of vinegar cream + 1% ethylene glycol + 2% ammonium chloride stone-induced liquid group, fed 28 days were sacrificed observing kidney tissue HE staining area of distribution of calcium oxalate crystals, measuring concentration of oxalic acid and calcium lev els of rats in each group. Results:The blank group compared with the other three groups, the distribution area of calcium oxalate crystals in renal tissue and the content of oxalate and calcium levels in the differences were statistically significant(p <0.05); the modeling group compared with the high-dose vinegar paste group, the distribution area of calcium oxalate crystals in renal tissue and the content of oxalate and calcium levels in the differences were statistically significant(p <0.05), while compared with the low-dose vinegar paste group, the distribution area of calcium oxalate crystals in renal tissue and the content of oxalate and calcium levels in the differences were not statistically significant(p> 0.05); the high-dose vinegar paste group compared with the low-dose vinegar paste group, the content of oxalate and calcium levels in the differences were statistically significant(p <0.05),the distribution area of calcium oxalate crystals in renal tissue were not statistically significant(p> 0.05). Conclusion:There is a preventive effect on urinary stone formation in rats by applying high-dose vinegar cream in normal consumption dose range, and its mechanism is that acetic acid can reduce the content of oxalate and calcium in nephridial tissue.