The Assessment Of The Classification Of Fetal Hypospadias By Prenatal Ultrasound

Objective To discuss the ultrasonic views and features and their value of prenatal diagnosis in classification of fetal hypospadias. Methods The 2D and 3D ultrasonic features of 33 cases with fetal hypospadias were retrospectively analyzed. The follow-up results of the birth and induced labor were collected and analyzed. Contrast the ultrasonic featuers between Proximal hypospadias and Penile hypospadias. Results 21 cases of fetal proximal hypospadias and 12 cases of fetal penile hypospadias were diagnosed by prenatal ultrasound. 19 cases in 21 of fetal proximal hypospadias were confirmed after fetal birth and induced labor. 1 case was congenital adrenal cortical hyperplasia and the other one was a normal girl with swollen labia. And 6 in 12 of fetal penile hypospadias were confirmed after fetal birth and induced labor. 4 cases were confirmed as false positive with nomal genital appearance. 1 case was penis adhesion to bent, 1 case was with redundant prepuce. Prenatal diagnostic sensitivity, specificity, positive predictive value and negative predictive value of fetal proximal hypospadias and penile hypospadias were 95.0%,75.0% and 71.4%,40.0% and 90.5%,50.0% and 83.3%,60.0% respectively. 6 cases did C hromosome analysis, two cases were 46(XX),threecases were 46(XY),onecasewere 45X(52)/46XY(48). Conclusions Due to the more typical ultrasonic features of fetal proximalhypospadias than the penile hypospadias, the accuracy rateof fetal proximalhypospadias is higher thanthe penile hypospadias. The main differential diagnosis offetal proximalhypospadias is female congenital adrenal cortical hyperplasia, while combining chromosome analysis can improve the diagnosis accurate rate.