| Background and purpose: To investigate the characteristics of cerebral vascular imaging and the risk factors of stroke in population with family history of stroke in rural areas of Ji County, Tianjin. And to provide epidemiological data for stroke prevention and treatment. Methods: 471 patients of first-ever stroke diagnosised by CT/MRI, whom came from 18 villages in Ji County, Tianjin China were identified during 2006-2012. The current study takes these people as probands. We divided all villages into three strata by geographical location: east, south and north, finally 75 probands were randomly sampled from each stratum. The research regards their first-degree relatives as population with positive family history of stroke, which contained 340 individuals alive. The subjects were selected from them, which should met the inclusion criteria:(1) residents aged 18 or older with no history of emigration or immigration,(2) no obvious neurologic impairment(modified Rankin Scale [mRS] ≤ 2 level,(3) those who were unable to complete the screening or follow-up because of other physical, mental, or environmental conditions were excluded. The final number of residents was 281(153 men, 54.4%; 128 women, 45.6%)whose date was analysised included in this study after undergoing required questionnaire, physical examination and brain CT and CTA image examination at the General Hospital of Tianjin Medical University. Results: The prevalence of the internal carotid artery calcification, the internal carotid artery stenosis, the internal carotid artery tortuosity, the incomplete of Willis circle, and the vertebrobasilar stenosis was 34.2%, 6.4%, 8.9%, 85.4%, 10% respectively. The prevalence of the internal carotid artery calcification and the vertebrobasilar stenosis were higher among male subjects than among female subjects(P<0.05). However, the internal carotid artery tortuosity rate was higher among female subjects than among male subjects(P<0.05). The prevalence of ICAC and VBS were increased along with the age(P<0.01), The Prevalence of Cerebrovascular lesions did not differ significantly between different schooling(P>0.05). The Prevalence of internal carotid artery calcification(P<0.01), internal carotid artery tortuosity(P<0.05) and vertebrobasilar stenosis(P<0.01) were higher in the hypertensione group than in the non-hypertension group. 38 subjects(21 men, 17 women) were stroke including 19 subjects with previous stroke history and 19 subjects were first observed by the CT examination. The Prevalence of internal carotid artery calcification(P<0.01) and internal carotid artery tortuosity(P<0.01) were significantly higher in the stroke group than in the non-stroke group. Intracranial aneurysms occurred in 29 subjects(10.3%), 15 were men(9.8%) and 14 were women(10.9%), and 6 subjects were belong to Family Intracranial aneurysms. Age, gender, hypertension, diabetes mellitus, body mass index,Triglyceride(TG), total cholesterol(TC), high-density lipoprotein(HDL-C), integrity of the Willis, cigarette smoking and alcohol consumption showed no statistically significant difference between intracranial aneurysm group and non intracranial aneurysm group(P>0.05). A total of 30 aneurysms were noted; 19(63.3%) located at internal carotid artery, 3(10%) located at the anterior communicating artery, one(3.3%) at the cerebral artery, 2(6.7%) at the cerebral artery, one(3.3%) at the middle cerebral artery, 3(10%) at the vertebral basilar artery and one(3.3%) at the posterior inferior cerebellar artery. According to the morphological classification, 22(73.3%) were the cystic one, 6(20%)the fusiformis one, and 2(6.7%) the blood drop one. There were 121(43.1%) subjects with variations involving an incomplete anterior CoW, including 58 men(37.9%) and 63 women(49.2%). There were 213(75.8%) subjects with variations involving an incomplete posterior circle of Willis, including 120 men(78.4) and 93 women(72.7). The results of multivariate logistic regression analysis indicated that Age, SBP, ICAC, and ICAT were independent risk factors for stroke. Conclusion: This is the first study on prevalence of cerebrovascular lesions in people with FHS from a population-based study. The prevalence of Cerebrovascular lesions and intracranial aneurysm in population with family history of stroke is high; most of intracranial aneurysms are cystiform and mostly locate in the internal carotid artery. Age, hypertension, ICAC and ICAT were risk factors of stroke in this population. |
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