Clinic Significance Of Monitoring Obstructive Sleep Apnea Syndrome Among The Patients With Coronary Artery Disease

Objective:The aim of our study was to assess the prevalence of obstructivesleep apnea syndrome (OSAS) in patients with chest pain and angiographicallyverified coronary artery disease(CAD).Additionally we analyzed theassociation of OSAS and coronary risk factors with CAD.Method:82consecutive selection patients were classified into two groups according to thecoronary angiography(CAG) results:CAD group(51 patients with verifiedCAD);normal group(31 patients with exclution of CAD.Overnightpolysomography(PSG) recordings for detection of OSAS was performed in 82patients, They were divided into three groups based on their nocturnal apneahypopnea index (AHI) detected by examination of polysomnography (PSG),mild OSAS group (10≤AHI＜20, 22 cases), moderate-to-severe group (AHI≥20, 20 cases) and control group (AHI＜10, 40 cases). Gensini Score forassessing the severity of coronary atherosclerosis were made in all threegroups.Mutiple logistic regression analysis was performed to assess OSAS andother coronary risk factors with CAD.Results:CAD patients were found tohave OSAS in 70%,normal subjects were found to have OSAS in 19%.Compared with the control group, the apnea-hypopnea index (AHI) wassignificantly higher in OSAS groups (14.5, 34.3vs 4.5). The minimal SpO₂were significantly lower (82.6%, 80.6% in OSAS groups than that 87.6% in the control group. The incidence of CAD was significantly higher[77% (17/22) and95% (19/20)] in OSAS groups than that [38% (15/40)]in the control group.The percentage of patients with single-coronary-vessel disease was 27% (6/22)in mild OSAS group, 20% (4/20) in moderate-to-severe OSAS group, and18%(7/40) in control group. The patients with multi-coronary-vessel diseasewere 50%(11/22) in mild OSAS group, 80%(16/20) in moderate-to-severeOSAS group, and 20%(8/40) in control group. Gensini Score was significantlyhigher in moderate-to-severe OSAS group(55) than that in control group(20).OSAS(OR5.66; 95%CI: 1.74-18.38; P=0.004)hypertension (OR3.79;95%CI: 1.20-11.98; P=0.023) and LP(a)(OR1.01; 95%CI: 1.00-1.02; P=0.014) were independently associated with CAD.Conclution:There is a highoccurrence of OSAS in patients with angiographically verified CAD.OSAS isindependently associated with CAD. OSAS might be a significant independentrisk factor of coronary atherosclerosis and CAD and should be taken intoaccount in CAD secondary prevention. Objective: To study the association between arterial stiffness index(ASI) andapnea hypopnea index(AHI) in patients combination of obstructive sleep apneasyndrome (OSAS) and coronary artery disease(CAD). Methods 82 consecutiveselection patients were classified into four groups according to the coronaryangiography(CAG) and polysomography(PSG)results:control(25 patients),OSAS(6patients),CAD(15 patients),OSAS with CAD(36 patients) groups.The AHI and ASIwere measured. Results: Compared with the CAD group, there were significantlyhigher values of ASI in OSAS with CAD group(77.44±47.68 vs 54.53±14.39, P=0.002).In OSAS with CAD group,ASI was positively correlated withAHI(r=0.786,P＜0.01). Conclusion: Arterial stiffness was more severe in patientswith OSAS and CAD,and was positively correlated with the severity ofOSAS,Thus,in the care of patients with CAD,particular monitoring and treatingOSAS is of great importance.