| Objective: Hepatitis B virus(HBV) infection continues to be a major public health issue worldwide. Recent reports show that the population of chronic HBV infection is about 24.8 million all over the world. Approximately 380-400 thousand people die from HBV-relative diseases in China, which threatens public health seriously. Studies find the relationship between Vitamin D Receptor(VDR) polymorphisms(Taq I, Fok I, Apa I, Bsm I) and risk of HBV infection. However, for different races of people in different regions, the results are inconsistent. The aim of this study was to further quantify the association between VDR polymorphisms(Taq I, Fok I, Apa I and Bsm I) with HBV infection by meta-analysis approach.Methods: A literature search was performed in databases of Pubmed, Embase, China National Knowledge Infrastructure(CNKI), Database of Chinese Scientific and Technical Periodicals(VIP), WANFANG with eligible inclusion and exclusion criteria. Finally, 15 published studies included 4218 cases and 2298 controls were included in this meta- analysis. Furthermore, the HWE of controls were detected by the chi square test for goodness of fit, P-value <0.05 was considered depart from HWE.Results: Finally, 15 published studies(8 in English and 7 in Chinese) included 4218 cases and 2298 controls were included in this meta- analysis. It is interesting to find Fok I genotype Ff increases risk of HBV persistent infection in codominant(OR2) model with no heterogeneity [Ff vs. ff: P <0.01, OR(95%CI) = 1.28(1.08-1.53), I2=0.0%]. In allele contrast model, the Fok I f allele decreases the risk of HBV [F vs. f: P<0.01, OR(95%CI) =1.25(1.10-1.42), I2=29.9%]. When compared FF with ff, the estimated OR1(95%CI) =1.53(1.18-1.98), P<0.01. Whereas no associations were founded about VDR Taq I, Apa I and Bsm I polymorphisms with HBV infection based on each comparison model.Conclusion: VDR- Fok I polymorphisms showed a closely associated with risk of HBV infection, and the Fok I f allele decreased the risk of HBV. |
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