| Objective:To investigate the clinical symptom and risk factors of diabetic seizures.Methods:The clinical data of 44 patients with diabetes related seizures were analyzed with the clinical classification, blood glucose, Na+, Plasma Osmotic Pressure, HbA1 c, EEG, brain MR, and the antiepileptic drugs.Results:1. Diabetic hyperglycemia(DH) related seizuresAmong the 28 patients,17 cases were male patients,11 cases were female patients. The mean age was 51.3 years old. Simple partial seizure without secondary generalized seizures(12/28,42.8%) was the most common, 8 patients(8/28,28.6%)showed complex partial seizure, 8 patients(8/28,28.6%) showed no obvious focal origin generalized tonic-closure seizures. Patients with poor glycemic control(HbA1c >9%) had significantly higher risk of generalized seizures(46.7% VS 7.7 %, p< 0.05)(p < 0.05).2. Diabetic ketoa-cidosis or hypertonic state associated seizuresAmong the 7 patients,6 cases were male patients,1case was female patients. The mean age was 45.7 years old, 2 patients(2/7,28.6%) had generalized tonic-clonic seizure, 2 patients(2/7,28.6%) showed status epilepticus,2 patients(2/7,28.6%) showed local motor seizure,1 patient(1/7,14.2%) showed Jackson seizure.3. Diabetic hypoglycemia related seizuresAmong the 9 patients,7 cases were male patients,2cases were female patients. The mean age was 45.3 years old.5 patients showed generalized tonic-clonic seizure(5/9,55.6%), 3 patients had complex partial seizure(3/9,33.3%), 1 patients had generalized tonic-closure seizures(1/9,11.1%).Conclusion:Simple partial seizure is the most common in patients with diabetic hyperglycemia related seizures; so as to diabetic hypoglycemia and keto-acidosis, generalized seizures are relatively common. Hb A1 c can be an important risk factor of seizures for patients with hyperglycemia. |
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