Analysis Of The Characteristics Of Virchow-Robin Spaces In Alzheimer’s Disease

ObjectiveTo study the Virchow-Robin spaces(VRS) characteristics in Alzheimer’s disease(AD) and analysis the correlation between Magnetic Resonance Imaging of VRS and AD.MethodsSeventy AD patients(AD group) and sixty-two normal controls(control group) were detected by brain MRI, and their VRS in the midbrain, basal ganglia, deep insular white matter and centrum semiovale were numbered and measured. The results were compared between the two groups.ResultsVRS were observed in multiple brain regions of AD groups, typically in basal ganglia.The discovery rate of VRS in AD group(49.1%, 34/70)was higher than that in control group( 24.2%, 15/62), the difference is statistically significant(P < 0.05).The number of VRS in AD group [(4.1±2.2)/case] was more than that in control group[(2.4±1.9)/case], the difference is statistically significant(P < 0.05).The diameter of VRS in AD group [(2.8±1.2)mm] was larger than that in control group [(1.8±0.5)mm], the difference is statistically significant(P < 0.05).Linear regression analysis showed the number, diameter of VRS in control group were both positive correlated with the age(r1 = 0.802, r2 = 0.902, all P < 0.05).ConclusionVRS in AD have its own characteristics,should cause the attention of clinical.