A Meta Analysis Of Mannitol Combined With Glycerin Fructose For The Treatment Of Cerebral Hemorrhage

Objective: To appraise whether it have difference between mannitol combined with glycerin fructose and only use mannitol for the treatment of cerebral hemorrhage, which provides relevant evidence-based basis for guiding clinical treatment of cerebral hemorrhage.Methods: We used literature retrieval through to the PUBMED、China national knowledge internet(CNKI), China biology medicine disc(CBM), VIP Chinese periodical database(VIP), Wanfang data knowledge service platform and manual retrieval, and formulate the inclusion and exclusion to screening literature; and to evaluate literature which had been included, heterogeneity inspection at the same time. If the effect of multiple resulted, we used fixed effect model; if not, used a random effects model.Results: Mannitol combined glycerol fructose significantly improved symptoms and nervous function in patients with cerebral hemorrhage, and the difference was statistically significant(RR = 1.12, P<0.01); Mannitol combined glycerol fructose significantly decreased impaired renal function and complications(RR = 0.34, P<0.01); Mannitol combined glycerol fructose significantly decreased severe unbalance of electrolyte after taking the medicine(RR = 0.31, P<0.01).Conclusion: Compared to use mannitol only, combination with mannitol and glycerin fructose could effectively improve the prognosis of cerebral hemorrhage patients, and reduce the side effects.