Intravenous Mannitol On Rabbit Cerebral Hemorrhage Cerebral Edema

Objective: To study if the cerebral edema can be alleviated by low dose mannitol in New Zealand white rabbits of intracerebral hemorrhage. Methods: Intracerebral hemorrhage (ICH) model of New Zealand white rabbits be established firstly . These rabbits were divided randomly into three large groups according to observational time. Rabbits in every large group were divided randomly into three therapeutic groups . In group A ,0. 5g/kg mannitol was infused ,Q12h . In group B, 0. 25g/kg mannitol was infused ,Q12h . In group C , no mannitol was used. The rabbits were executed by air embolism at 24 48 72 120 hours. Wet weights of brain tissues, which the volume was about 1 mm~3, around the hematoma were weighted .Then , the brain tissues were dried in an oven at 110℃ .Later , dry weights of the brain tissues were weighted.At last , water content was calculated as the per centage change between wet weight and dry weight .Results (1) After being treated for 24 hours, water contents of the tissues around the hematoma of group A have significant difference compare with that of group B (p=0. 075) . Yet, have no significant difference between group A and group C (p=0. 450) . Synchronously, water contents of the tissues around the hematoma of group B have significant difference compare with that of group C (p=0.016) . (2) After being treated 48 hours, neither water contents of the tissues around the hematoma of group A have significant difference compare with that of group B (p=0. 521) or group C (p=0. 934) ,. nor water contents of group B have significant difference compare with that of group C(p=0. 719). (3) After being treated 72 hours, neither water contents of the tissues around the hematoma of group A have significant difference compare with that of group B (p=0.112) or group C (p=0. 420) ,.nor water contents of group B have significant difference...