Levels Of Sex Hormones And P-selection In Postmenopausal Women With Coronary Heart Disease Taking Aspirin And Their Relationships

Objective: 1.To observe the changes of plasma platelet activating substance P-selection in postmenopausal women with coronary heart disease after taking aspirin.2.To observe the relationship between sex hormone levels and P-selection in postmenopausal women with coronary heart disease after taking aspirin.3.To provide a theoretical basis for the further study of anti platelet therapy in postmenopausal women with coronary heart disease.Methods: 103 postmenopausal women who were hospitalized in the First Affiliated Hospital of Shihezi University Medical College from December 2014 to August 2015(aspirin group 67cases/Non aspirin group 36 cases) were selected. The levels of sex hormones and P-selection in the two groups were measured, and the results were compared between the two groups.Results: Compared with non aspirin group, aspirin group P- selection was significantly lower than that of E2, and was significantly higher(P < 0.05). There is a certain correlation between E2 and P- selection(r=-0.354, P < 0.01). There was no correlation between LH, FSH, PROG,PRL, TESTO and P-, and there was no statistical significance(P > 0.01).Conclusions: 1.In postmenopausal women with coronary heart disease after taking aspirin can inhibit the expression of P- to reduce the level of P- in plasma.2.In postmenopausal women with coronary heart disease, the plasma levels of Pselection- and estradiol(E2) have a negative correlation with aspirin, which may affect the inhibitory effect of aspirin on P-selection.