Clinical Observation Of Comprehensive Treatment On Anterior Ischemic Optic Neuropathy

Objective:To observe the clinical effect of comprehensive treatment of anterior ischemic optic neuropathy.Methods:From January 2014 to July 2015, 42 eyes of 40 patients with anterior ischemic optic neuropathy in First Hospital of Shanxi Medical University were used as the research objects. All the patients were actively controlled systemic disease, at the same time given systemic and local comprehensive therapies, such as glucocorticoid hormone, vasodilator,neurotrophic drugs and compound anisodine injected around superficial temporal artery,with 15 days for a course of treatment, then follow-up 30~45 days.Results:In 40 cases(42 eyes) of the patients, 15 females and 25 males. Among them, 10 patients with diabetes, 24 patients were hypertension, 22 patients with hyperlipidemia, and18 patients with a history of smoking. In 40 patients, the age ranged from 42 to 71 years with an average age of 55.52 years. The course of disease was 2 days to 1 month, and the average was 11.48 days. Visual acuity of 42 eyes was improved significantly after 15 days treatment(P<0.01). After a follow-up observation of 30 to 45 days, visual acuity improved more significantly than 15 days treatment(P=0.029). Before treatment the mean visual field defect was 16.14±5.05 dB, but it was 11.56±3.74 dB after 15 days treatment, which was significantly reduced(t=12.63, P<0.01). Then after a 30 to 45 days follow-up observation, the mean visual field defect was 9.53±3.89 dB, lower than 15 days treatment(t=8.94, P <0.01). Compared the total effective rate of 90.48%(30 to 40 days follow-up observation) with 78.57%(15 days treatment), it was not considered to be statistically significant(P=0.113).Conclusions:The comprehensive treatment of anterior ischemic optic neuropathy has a significant effect, can effectively improve the vision, reduce the field defect and significantly reduce the optic papilla edema.