Relationship Between Plasma Levels Of Soluble Receptor Of Advanced Gyration End Products And Cardiac Function In Patients With Sepsis

Objective:To explore the relationship between plasma levels of soluble receptor of advanced glycation end products(sRAGE), brain natriuretic peptide(BNP) and cardiac function in patients with sepsis.Methods: A total of 83 sepsis patients cured in the first hospital of Lanzhou university from2014-01 to 2015-06 were studied. Plasma levels of sRAGE, BNP were examined at 24 h after admission and they were evaluated by APACHEII scores. According to BNP levels, the patients were divided into 2 groups: Normal cardiac function group, the patients with BNP<500 pg/ml, n=32 and Cardiac dysfunction group, the patients with BNP≥500 pg/ml, n=51. The cardiac function as stroke volume(SV), LVEF, minute volume, E/A were examined by echocardiography.The above indexes were analyzed and compared between 2 groups, the relationship between plasma levels of sRAGE and the occurrence of sepsis was assessed by Logistic regression analysis.Results:Compared with Normal cardiac function group, the patients in Cardiac dysfunction group presented decreased SV, LVEF, minute volume and E/A; increased APACHEII scores and sRAGE, all P<0.01. Plasma levels of sRAGE in sepsis patients were positively related to BNP(r=0.90, P<0.05) and APACHEII scores(r=0.85, P<0.05). Logistic regression analysis indicated that plasma levels of sRAGE(OR=1.019, 95% CI 1.004-1.035, P<0.05) was independently related to cardiac function in patients with sepsis.Conclusion:Plasma levels of sRAGE were independently related to cardiac function in patients with sepsis.