The Distribution And Risk Factors Of Chronic Obstructive Pulmonary Disease With Metabolic Syndrome

Objectives:Investigate the prevalence of metabolic syndrome in hospitalized chronic obstructive pulmonary disease (COPD) patients, and the correlation with gender, age, smoking, and inflammatory indicators.Methods:A retrospective analysis was conducted with the clinical data of COPD patients, who discharge from respiratory department of The First Affiliated Hospital of Kunming Medical University from September 1,2013 to December 31, 2014.Calculatethe prevalence of metabolic syndrome in hospitalized chronic obstructive pulmonary disease (COPD) patients and analyze possible risk factors with multiple Logistic regression analysis.Results:The study included 1142 subjects,848 cases of male (74.3%),294 cases of female (25.7%), the sex ratio is 2.88:1; The youngest was 30 years old, eldest was97 years old, average age was70.55± 10.661 years old. only 164COPD patients combined metabolic syndrome (14.4%),the rest 978 patients didn’t coexist with metabolic syndrome (85.6%).In all of the COPD patients, there isn’t differences between male and female with the prevalence of high blood glucose, low high-density lipoprotein (HDL).However obesity, high blood pressure, high triglycerides have gender differences. Female is a risk factor for obesity, high blood pressure, high triglycerides in COPD patients. In different stage of lung function, there is no difference in incidence of obesity, high blood glucose. On the contrary, statistical differences show in blood pressure, high triglycerides and low HDL with different stage of lung function. The incidence of high blood pressure, low HDL decreased with the increase of lung function classification. The highest incidence of high triglycerides is in GOLD2, the lowest in the GOLD4.In the COPD patients coexist with metabolic syndrome, the incidence of hypertension, obesity, diabetes, hyperlipidemia were 92.1%,72.0%,56.7%,11.6%, and no gender, age differences. Sex, smoking, age and HDL has no correlation with COPD coexist metabolic syndrome, however blood glucose, triglyceride, BMI was positively associated. COPD with metabolic syndrome group compared with COPD without metabolic syndrome group, fibrinogen level has no statistical difference (P= 0.465), which indicates that fibrinogen is meaningless in predicting COPD with metabolic syndrome. The positive rate of CRP is higher in COPD with metabolic syndrome group than control group (P= 0.047), which may relate to the elevated system inflammation in COPD patients who coexist metabolic syndrome. In all of the COPD patients, the incidence of metabolic syndrome in different lung function COPD group from the mild to very severe were 16.9%,16.4%,7.3%,4.8%, the difference was statistically significant (P= 0.005),imply that in COPD patients, better lung function combination of a high incidence of metabolic syndrome, and the incidence of COPD with metabolic syndrome decrease with the lung function decline. All of the patients can be divided into COPD with metabolic syndrome and simple COPD group, compared their lung function,there are differences between the two groups in lung function (P< 0.05), lung function is better in COPD with metabolic syndrome than COPD without metabolic syndrome group.Conclusions:1.In hospital patients with chronic obstructive pulmonary disease, female is a risk factor for obesity, high blood pressure, high triglycerides. In different lung function group, the incidence of high blood pressure, low HDL decreased with the increase of lung function classification; The highest incidence of high triglycerides is in GOLD2, the lowest in the GOLD4.2.1n hospitalized AECOPD patients, the percentage of coexist metabolic syndrome is14.4%.In COPD with metabolic syndrome patients, the incidence of different metabolic disorders in high and low order is hypertension, obesity, diabetes, hyperlipidemia, and there is no difference with gender and age.3.Blood glucose, triglyceride, and BMI was positively correlated with COPD coexist with metabolic syndrome,but there is no correlation with sex, smoking, age and HDL.4. The metabolic syndrome can increase the systemic inflammation in COPD patients; Fibrinogen is meaningless in the diagnosis of COPD combined metabolic syndrome.5.1n COPD patients, with the decline of lung function, the incidence of metabolic syndrome decrease..