| Objective:1.To observe the effects of Liandou Qingmai Recipe on the improvement of the clinical symptoms in patients with unstable angina pectoris after Percutaneous Coronary Intervention (PCI) with the syndrom of phlegm stasis and blood stasis and Stasis hot alternating knot.2.To observe the effects of Liandou Qingmai Recipe on the hs-CRP and IL-6 levels in patients with coronary heart disease after PCI.3.To explore the primary theoretical foundation of restraining the inflammation reaction in patients with unstable angina pectoris after PCI with the syndrom of phlegm stasis and blood stasis and Stasis hot alternating knot and effectiverate treatment methods of treating the complication after PCI.Method:Select 60 in-patients in accordance with the syndrom of phlegm stasis and blood st asis and stasis hot alternating knot with unstable angina pectoris in wuxi hospital of tra ditional Chinese medicine.Then randomly assign them intocontrol group (traditional Chin ese medicine treatment group) 30 cases and treatment group (western medicine treatme nt group) 30 cases.It gives control group standard western medicine treatment, includin g against ischemic (nitrates β receptor blockers, calcium channel blockers), anticoagulati on (heparin or lowmolecular heparin), platelet (aspirin and/or clopidogrel) and regulatin g lipid metabolism (statins), and other drugs. Treatment group are given Liandou Qingma i Recipe granula on the basis of the standard western medicine treatment (forsythia, rhi zoma coptidis, wild liaodou, cortex moutan, rhizomaanemarrhenae, radix paeonia rubra, semen raphani, it is configurated by manufacturing laboratory,2 times a day, starting ta king after PCI, taking to 4 weeks after PCI).At last, to observe the improvement of TCM clinical symptoms of two groups patients.In addition, to measure the LDL-C level s after PCI and four weeks after PCI, to measure the hs-CRP、IL-6 and cTnl levels bef ore PCI、after PCI and four weeks after PCI. Eventually, to statistically analysis.Result:1.TCM syndrome scoring of control group is 8.80 24 hours after PCI,TCM syndrome scoring of control group is 5.27 four weeks after PCI.They are statistically significant (P<0.05). TCM syndrome scoring of treatment group is 9.20 24 hours after PCI,TCM syndrome scoring of treatment group is 3.87 four weeks after PCI.They are statistically significant (P<0.05).2.The total effectiverate of TCM syndrome of control groupwas 36.7% four weeks after PCI;And the total effectiverate of TCM syndrome of treatment group was 63.3% four weeks after PCI. The curative effect of treatment group is significantly better than the control group(P<0.05).3.The hs-CRP levels of treatment group and control group before PCI respectively are 3.85±0.74,3.07±0.47,the hs-CRP levels of treatment group and control group 24 hours after PCI respectively are 6.47±0.92,7.14±0.67,the hs-CRP levels of treatment group and control group four weeks after PCI respectively are 3.05±0.50、5.05±0.69.The hs-CRP levels of 24 hours after PCI have a larger increase than before PCI, the difference intergroup is statistically significant (P<0.05). The hs-CRP levels of four weeks after PCI have a larger decrease than 24 hours after PCI, the difference intergroup is statistically significant (P<0.05). The hs-CRP levels of before PCI and 24 hours after PCI between the two groups show no significant difference (P>0.05).The hs-CRP average levels four weeks after PCI have a larger decrease in the treatment group than the control group, the difference intergroup is statistically significant (P<0.05)4.The IL-6 levels of treatment group and control group before PCI respectively are 5.36±0.53、5.79±0.47,the IL-6 levels of treatment group and control group 24 hours after PCI respectively are 8.71±0.57、9.53±0.38,the IL-6 levels of treatment group and control group four weeks after PCI respectively are 4.33±0.39、7.44±0.42.The IL-6 levels of 24 hours after PCI have a larger increase than before PCI, the difference intergroup is statistically significant (P<0.05). The IL-6 levels of four weeks after PCI have a larger decrease than 24 hours after PCI, the difference intergroup is statistically significant (P<0.05). The IL-6 levels of before PCI and 24 hours after PCI between the two groups show no significant difference (P>0.05).The IL-6 average levels four weeks after PCI have a larger decrease in the treatment group than the control group, the difference intergroup is statistically significant (P<0.05)5.The cTnI levels of control group respectively are 0.018±0.051、0.019±0.050、 0.017±0.052 before PCI、after the two groups 24 hours after PCI and four weeks after PCI; The cTnI levels of treatment group respectively are 0.017±0.052、0.018±0.059、0.016±0.058 before PCI、after the two groups 24 hours after PCI and four weeks after PCI。The cTnI levels of two group between the two groups and intergroup show no significant difference (P>0.05) before PCI、after the two groups 24 hours after PCI and four weeks after PCI. But the cTnI average levels of 24hours after PCI get higer than postoperation. The cTnI average levels of four weeks after PCI get higer than 24 hours after PCI.6. The LDL-C levels of treatment group and control group 24 hours after PCI respectively are 3.56±1.56、3.66±1.31, the LDL-C levels of treatment group and control group four weeks after PCI respectively are 1.72±0.91、2.74±1.16.The cTnl average levels of two groups intergroup four weeks after PCI have a larger decrease in the treatment group than the control group, the difference is statistically significant (P<0.05). The LDL-C levels between the two groups 24 hours after PCI show no significant difference (P>0.05)。The cTnI average levels four weeks after PCI have a larger decrease in the treatment group than the control group, the difference is statistically significant (P<0.05)Conclusion:1. The study shows that Liandou Qingmai Recipe treatment group can effectively relieve patients symptoms compared with the pure western medicine.2. The study shows that the levels of hs-CRP and IL-6 24 hours after PCI have a significant rise in relative to preoperation.It suggests that PCI can cause or aggravate inflammation reaction of coronary artery arteria coronaria.3.The study shows that Liandou Qingmai Recipe can effectively restrain inflammatio n reaction, and decrease the hs-CRP and IL-6 levels compared with the pure western medi cine in patients with unstable angina pectoris after PCI.It can infer this is the possible m echanism of action of Liandou Qingmai Recipe on the improvement of the clinical symp toms and decreasing the hs-CRP and IL-6 levels.4. The study shows that Liandou Qingmai Recipe can markedly decrease the LDL-C levels compared with the pure western medicine. |
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