| Background:As human dig deeper into HP, HP infected related stomach disease is widely accepted as an infectious disease. We believe that the refractory HP infection is relevant to reinfection from not cutting off infection routes. Cutting off infection routes is helpful to improve eradication of refractory HP infection.Purpose:Triple Therapy is adopted to coordinate with behavioral intervention to treat the refractory HP infection to explore the effect of behavioral intervention in the treatment of refractory HP infection. Syndromes distribution characteristics of refractory HP infection patients are summarized and analyzed.Method:Select 60 patients (Hp positive for many times or failed after several treatment) meeting the Hp diagnostic criteria from the outpatient and inpatient at the Spleen and Stomach Department of Nanjing Hospital of T.C.M. during February 2015 to January 2016 and divide them by random allocation and blind method into control group (30 cases) and treatment group (30 cases). Treat the control group with PPI triple therapy and bismuth of omeprazole 20mg twice/day, Amoxicillin-clavulanate potassium 1.0g twice/day, (Metronidazole instead for patients allergic to penicillin) Clarithromycin Tablet 0.5g twice/day, bismuth potassium citrate capsule 220mg twice/day. Treat the treatment group with PPI triple therapy and behavioral intervention that cuts off the route of transmission. The course of treatment for both groups is lOd. Clinical observation cycle is one month. After one month, C13 breath test is used to recheck the HP eradication. Statistical analysis is conducted on related data to compare the clinical effects before and after treatment. Investigation and analysis on patients are conducted in terms of gender, age, smoke, drink, collective dwelling and eating out. Research on the Syndromes Distribution of refractory Helicobacter Pylori Infected Patients is carried out to discuss the regulations of Syndromes Distribution.Result:(1) After treatment, the effective rate of the control group and treatment group is 36.7% and 56.7% respectively. Compared to the control group, the clinical effective rate of the treatment has improved but it does not have statistical difference (P>0.05). Eradication of HP in treatment group has statistical significance (P<0.05) with collective dwelling and eating out. Patients in treatment group obviously changed living habit after behavioral intervention treatment. Reducing times of eating out is motivator for cure of refractory HP infection. (OR is 29; 95% confidence interval is 3.5～241.1) (2) In the HP infection patients in this research, sequence of the characteristics of T.C.M. symptom distribution from the highest to the lowest is as following:abdominal distension (75.0%)> belching acid regurgitation (65.0%)> ozostomia (48.3%)> loose stool (31.7%)> stomachache (16.7%). Among the symptom distribution, most performances are abdominal distension and belching acid regurgitation. In the HP infection patients in this research, sequence of the characteristics of T.C.M. syndrome distribution from the highest to the lowest is as following:spleen deficiency and dampness (28.3%)>liver-qi attacking stomach (21.7%)>deficiency-cold in spleen and stomach (20.0%)>stagnancy heat of the liver and stomach (15.0%)>cold-heat complication (11.7%)>stagnated blood of stomach meridian (3.3%).Conclusion:This research indicates that behavioral intervention is helpful to eradicate HP. Cutting off infection routes is necessary in treatment of HP. Among the refractory helicobacter pylori infected patients, spleen deficiency and dampness occurs more commonly than others. |
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