Effect Of Different Interventions Of Oral Helicobacter Pylori On The Eradication Rate Of Helicobacter Pylori Infection In Stomach

Objective:To investigate the effect of different interventions of Helicobacter pylori on the eradication rate of Helicobacter pylori in the stomach..METHODS:A total of 300patients who underwent¹⁴C breath test in the Department of Gastroenterology,Xinjiang Autonomous Region People's Hospital from January to February 2008,were enrolled in the¹⁴C-urea breath test(¹⁴C-urea breath test,¹⁴C-UBT)to detect Helicobacter pylori infection in the stomach,oral Helicobacter pylori test?rapid urease test?to detect oral Helicobacter pylori infection,select 165 gastric and oral Helicobacter pylori positive(O⁺G⁺Patients were randomly assigned to the group,and the O⁺G⁺group was given four anti-Helicobacter pylori drugs and four anti-Helicobacter pylori drugs+chlorhexidine injection,gastric Helicobacter pylori-positive,oral Helicobacter pylori-negative patients?G⁺O^-?A total of 53 patients were given anti-Helicobacter pylori drugs.After 4 weeks of treatment,¹⁴C-UBT was used to detect the eradication of Helicobacter pylori in the stomach and the positive rate of oral Helicobacter pylori by oral Helicobacter pylori test.Results:1.Helicobacter pylori rapid urease test showed that the positive rate of oral Helicobacter pylori was 62%?186/300?in 300 patients,and the positive rate of Helicobacter pylori in 72 breath test was 72.6%?218/300?.The rate of Helicobacter pylori-positive oral Helicobacter pylori-positive patients?G⁺O⁺?was 75.00%?165/218?,and the positive rate of?G⁺O^-?in patients with Helicobacter pylori-positive oral Helicobacter pylori was 24.3%?53/218?,Helicobacter pylori-negative patients with oral pyloric screw positive?G^-O⁺?positive rate of 13.4%?11/82?,gastric Helicobacter pylori-negative patients with oral pyloric screw negative?G^-O^-?proportion of 86.5%?71/82?.Chi-square test showed that the positive rate of oral Helicobacter pylori in patients with Helicobacter pylori and oral Helicobacter pylori positive?G⁺O⁺?was significantly higher than that in Helicobacter pylori-positive group?G⁺O^-?The positive rate of patients was statistically significant?P=0.03<0.05?.2.After 4 weeks of treatment,¹⁴C-UBT was re-examined to understand the eradication rate of Helicobacter pylori in the stomach and the eradication rate of oral Helicobacter pylori in the oral Helicobacter pylori test.Helicobacter pylori positive Helicobacter pylori positive group?O⁺G⁺,quadruple drug alone?was 58.2%?39/67?,15 cases were lost to follow-up;oral Helicobacter pylori-negative group Helicobacter pylori positive group?O^-G⁺,quadruple drug alone?was 83.3%?25/30?,and 23 patients were lost to follow-up.There was a statistically significant difference between the two groups??²=4.242,P=0.039<0.05?.The eradication rate of Helicobacter pylori-positive,oral Helicobacter pylori-positive mouthwash group?O⁺G⁺+S,oral quadruple drug plus chlorhexidine mouthwash?was87.1%?61/70?,and 13 patients were lost to follow-up.Helicobacter pylori-positive,oral Helicobacter pylori-positive group?O⁺G⁺,quadruple drug alone?was 58.2%?39/67?,and15 patients were lost to follow-up.There was a statistically significant difference??²=14.538,P=0.000<0.05?3.After 4 weeks of drug treatment,the eradication rate of oral Helicobacter pylori in O⁺G⁺group and O⁺G⁺S group was compared.O⁺G⁺group had oral Helicobacter pylori eradication rate of 44.8%?30/67?,The eradication rate of oral Helicobacter pylori in O⁺G⁺S group was 75.7%?53/70?,and the difference between the two groups was statistically significant??²=13.722,P=0.000<0.05?.Conclusion:There is a correlation between oral Helicobacter pylori infection and Helicobacter pylori infection.Clean oral cavity can improve the eradication rate of conventional anti-Helicobacter pylori drugs.Conventional quadruple drugs have no eradication effect on oral Helicobacter pylori.Conventional quadruple drugs Combined chlorhexidine gargle for oral Helicobacter pylori-positive,Helicobacter pylori-positive patients can improve the eradication rate of Helicobacter pylori.