Clinical Survey And Syndrome Differentiation Of 102 Breast Cancer Patients

ObjectiveThe purpose of this clinical survey was to study and analyze the syndrome differentiation; the basic characteristics including age, occupation, marital status and family history; pathological stages; tumor markers, and immunohistochemistry in breast cancer patients to find the relationship between TCM syndrome differentiation and clinical data.MethodsThe data of 102 patients of Jiangsu Province Hospital of Chinese Medicine in inpatient department of oncology satisfying the inclusion criteria were collected with the help of special form designed for this study and was analyzed using MS Excel and SPSS 21.0 software.ResultsThe analysis of data of 102 patients had following results:1. The incidence of breast cancer was high among 50-59 years age group with minimum age of 25 years and maximum age of 83 years (mean age-58.38 ± 12.04).2. While analyzing the stages and histo-pathological examination, most of the patients were of Ⅱ-stage (39.2%) followed by Ⅲ and Ⅳ stage (27.5% each), and 83.3% were of invasive ductal adenocarcinoma.3. Eight syndrome were found. They were accumulation of phlegm and blood stasis (33.3%); qi and blood deficiency (22%); liver qi stagnation with spleen deficiency (14.7%); vital-qi deficiency with toxin accumulation (11.8%); liver and kidney yin deficiency (9.8%); liver depression and qi stagnation (2.9%); qi-yin deficiency (2.9%), and lung and spleen qi deficiency (2%) respectively.4. While analyzing the distribution of syndrome differentiation and stage, vital-qi deficiency with toxin accumulation (66%) was the main syndrome in first stage. In second stage, accumulation of phlegm and blood stasis (40%); deficiency of qi and blood (23%), and liver qi stagnation with spleen deficiency (20%) were three major syndrome. In third stage, accumulation of phlegm and blood stasis (39%); vital-qi deficiency with toxin accumulation (21%), and liver qi stagnation with spleen deficiency (14%) were three major syndrome. In fourth stage, accumulation of phlegm and blood stasis (25%); liver and kidney yin deficiency (25%), and qi and blood deficiency (21%) were three major syndrome. 5. In the analysis of syndrome differentiation and histopathological diagnosis, accumulation of phlegm and blood stasis (35%); qi and blood deficiency (21%); liver qi stagnation with spleen deficiency (13%), and liver and kidney yin deficiency (12%) were the most common syndrome in invasive ductal carcinoma. 6. In 102 patients,14 cases of TNBC were found. The syndrome in TNBC were accumulation of phlegm and blood stasis (42.9%); qi and blood deficiency (35.7%); liver qi stagnation with spleen deficiency (14.3%), and vital qi deficiency with toxin accumulation (7%).ConclusionA total of eight syndrome:accumulation of phlegm and blood stasis; qi and blood deficiency; liver qi stagnation with spleen deficiency; vital-qi deficiency with toxin accumulation; liver and kidney yin deficiency; liver depression and qi stagnation; qi-yin deficiency, and lung and spleen qi deficiency were found.