| Objective: To learn mycoplasma pneumoniae(MP) infection situation of children’s respiratory tract infection in Soochow area,through analysising epidemiological characteristics of MP infection in children of soochow region, to provide evidence based medicine for the endemic prevention and treatment of mycoplasma infection.Methods: We enrolled 17820 cases of children with respiratory tract infections,who were hospitalized in respiratory department in Children’s Hosptital of Soochow University from January 2006 to December 2014.The sterile pressure suction method was adopted to collect fresh sputum samples,We used polymerase chain reaction(PCR)to detect MP-DNA level,while using quantitative ELISA to detect serum antibody of mycoplasma pneumoniae(MP-IgM and IgG),for Some suspected cases,we detected serum specimens of acute phase and convalescence.Subjects with positive of MP- DNA and/or MP serum antibody were defined as the MP infection.We analyzed all the clinical features and laboratory datas by retrospective statistical methods.Results: Among 17820 cases of children with respiratory tract infections, there were 5395 cases with MP infection, the total positive rate was 30.27%, In 9 years,the positiveratesofMPinfectionwere26.50%,31.18%,33.98%,40.35%,24.43%,20.04%,30.44%,40.38%,28.25%,respectively.The positive rates of 2009 and 2013 were 40.35%, 40.38%, respectively, which were increased significantly, Compared with the other years(P<0.05). MP infection could happen all the year round,the incidence rates of summer and fall were higher than that of winter and spring, the infection rate of summer was the highest,while which of winter was the lowest,compared with other seasons, which had statistical significance(P < 0.05). On the distribution of gender, the infection rate of boys(27.49%) was higher than that of girls(34.90%),which had statistical significance(P < 0.05). MP infection had significant differences in age distribution, the infection rate of < 1 year old group(15.75%) was the lowest, On the contrary, > 7 year old group(59.42%)had the highest incidence, the morbidity tended to increase as the age increased, and the differences between each group had statistical significance(P < 0.05).In the diseases with MP infection,lobar pneumonia had the highest infection rate(76.42%), followed by interstitial pneumonia(47.20%), bronchial asthma(41.57%), the infection rates of upper respiratory infection, bronchitisand bronchial pneumonia were lower, the positive rates were 27.85%, 29.87%, 26.24%, respectively. The positive rate of lobar pneumonia had significant difference with other diseases(P < 0.05). MP infection rate in patients with wheezing symptoms was 27.00%, Proportion of MP infection in wheezing patients was higher in summer and autumn, compared with that in winter and spring(P < 0.05). The clinical manifestations and CRP values of MP infection in different age groups were different, In the probability of cough, There is no significant difference between >3 year old age group and ≦3 year old age group(P>0.05), The fever incidence of former was significantly higher than that of the latter, while the wheezing incidence of former was significantly lower than that of the latter, and the difference had statistically significant(P<0.05), The level of CRP in patients with MP infection was higher than which of normal,The CRP level of >3 year old age group was significantly higher than which of ≦3 year old age group, the difference had statistically significant(P<0.05).the total positive rate of liver damage caused by MP infection was 8.28%, lower than that of non Mycoplasma respiratory tract infection(15.26%). In MP infection group,the incidence of Lobar pneumonia combined liver damage(10.84) was the highest, compared with other groups, the difference had statistically significant(P<0.05).Conclusions:(1) The positive rate of MP in recent nine years of Soochow area was 30.27%,the positive detection rate of MP in these years had a periodical fluctuation trend, outbreaks of Mycoplasma occurred in 2009 and 2013.(2) MP infection could occur in all age groups,The infection rate was positively correlated with the age of the infected patients.(3) MP could cause disease in the whole year,the positive rate of MP was highest in summer,while lowest in winter.(4) MP infection had significant gender differences, the incidence of girls was higher than boys.(5) the most common clinical symptoms of MP infection were cough, fever and wheezing,the clinical manifestations of different age groups were different.(6) the incidence of abnormal liver function caused by Mycoplasma respiratory tract infection was lower than that of non Mycoplasma respiratory tract infection.(7) abnormal liver function caused by Mycoplasma respiratory tract infection was most occured in lobar pneumonia. |
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