Epidemiological Investigation And Analysis Of Mycoplasma Pneumoniae Infection In Different Populations In Pukou District Of Nanjing City

Purposes:To investigate the infection status of MP in different populations,to explore the epidemiological characteristics of MP infection in Pukou District of Nanjing and its correlation with temperature and air quality,and to provide evidence for clinical diagnosis and prevention of MP infection.Methods:Using the passive agglutination method to detect MP antibody in 14035 patients with respiratory infections who were treated in Pukou Hospital of Nanjing from from January 2016 to December 2018,the differences in MP infection between different years,seasons,gender,age,outpatients and inpatients were investigated.The meteorological data(monthly average temperature and AQI)of Pukou District from January 2016 to December 2018 were collected to analyze the relationship between MP infection and monthly mean temperature and AQI.The content of procalcitonin in201 patients was detected by dry immunofluorescence,and the value of procalcitonin in diagnosis and treatment of MP infection in patients with respiratory tract infection was discussed.Excel 2003 was used to collate data and SPSS19.0 software was used for statistical analysis.The positive rate of different groups was compared by chi-square test.The correlation was analyzed by Pearson correlation analysis.The mean comparison was compared by one-way ANOVA,with P<0.05 as the difference with statistical significance.Results:From January 2016 to December 2018,14035 patients were tested for MP antibody.The total positive rate was 52.58%.The MP infection rate was the highest in2016.The infection rate of MP decreased year by year in the following two years.There was a significant difference in the infection rate of MP in three years(?~2=254.768,P﹤0.05).Female MP infection rate was 55.65%,male 49.68%,female was higher than male.There was a significant difference between female and male(?~2=50.023,P﹤0.05).The MP infection rate of outpatients was as high as60.48%,which was significantly higher than that of hospitalized patients(46.84%).There was a significant difference between the two groups(?~2=255.537,P﹤0.05).MP infection occurred throughout the year.The infection rate of MP was 47.94%in spring,37.59%in summer,53.13%in autumn and 66.24%in winter.The infection rate of MP was the highest in winter and the lowest in summer.There was significant difference in the infection rate of MP among different seasons(?~2=588.962,P﹤0.05).The infection rate of MP increased with age from 0 to 9 years old,and then decreased with age.There was significant difference in the infection rate of MP among different age groups(?~2=902.975,P﹤0.05).The MP infection rate was moderately negatively correlated with monthly mean temperature(r=-0.758,P<0.052),and was moderately positively correlated with AQI(r=0.608,P<0.05).Patients with high MP antibody titers had higher PCT levels than those with low MP antibody titers,but were significantly smaller than patients with respiratory bacterial infections.Conclusion:1.The infection rate of MP in patients with respiratory tract infection in Pukou District of Nanjing from 2016 to 2018 is 52.58%,and the annual MP infection rate showed a decreasing trend year by year.There are significant gender difference in MP infection.The infection rate of MP in female is higher than that in male.The infection rate of MP in outpatients with respiratory infection is higher than that in hospitalized patients.2.MP infection can occur all year round,but there are seasonal differences.The infection rate of MP is the highest in winter,followed by autumn and spring,and the lowest in summer.3.People of all ages are susceptible to MP.The MP infection rate of children aged≤9 years increases with age,The MP infection rate of people>9 years old decreases with age.Infant MP infection rate is the lowest,and school age group have a high incidence of MP infection.4.Meteorological factors have an impact on the rate of MP infection.The rate of MP infection decreases with increasing temperature and increases with the increase of AQI.5.PCT is mildly elevated in patients with MP infection.PCT detection is helpful for early diagnosis of MP mixed bacterial infection and can be used as a basis for clinical use of antibiotics.