A Study On The Non-Motor Symptoms In Parkinson Disease And Analysis On Related Influencing Factors

OBJECTIVES:To investigate Parkinson’s Disease (PD) patients’ no-motor symptoms (NMS) and related influencing factors.METHODS:67 cases of patients diagnoused PD in First Affiliated Hospital of Guangxi Medical University were selected from May,2015 to December,2015. They were tested by using Non-Motor Symptoms Questionnaire (NMSQuest) to evaluate PD patients’no-motor symptoms. The Unified Parkinson’s Disease Rating Scale (UPDRS), Modified Hoehn-Yahr rating scale (H-Y) were also performed. The data were performed using SPSS19.0 for Windows.RESULTS:(1) Among 67 cases of PD,66 (98.5%) patients had at least one NMS. The Incidence of constipation is the highest (65.7%), followed by forgetfulness (62.7%) and insomnia (62.7%), depression (61.2%), anxiety (58.2%), sweating (55.2%), difficulty concentrating (50.8%), vivid dreams (50.8%). (2)There are 65 patients appear autonomic nerves disorders(97.0%), 58 patients appear mental disorders (86.6%),57 patients appear sleep disorders (85.1%),48 patients appear sensation disorders (71.6%). (3) Significant relationship can be seen between sleep disorders and H-Y stage in all types of NMS (P> 0.05). Voiding dysfunction, lower extremity edema, difficulty swallowing, difficulty concentrating, delusions, hallucinations, apathy are significantly different at different stages in the H-Y (P<0.05). (4)The scores of sensory disorders and the rates of feelings of sad and depression, feelings of anxiety, unexplained pain,weight loss and RLS were significantly higher in female in PD group than those in male (all P<0.05). (5) The incidence rate of NMS is related to age (r=0.279, P<0.01), age of onset (r=0.242, P<0.05), H-Y grade (r=0.390, P<0.01), total UPDRS score (r=0.540, P<0.01), UPDRS part Ⅰ total score (r=0.602, P<0.01), UPDRS part Ⅱ total score (r=0.532, P<0.01), UPDRS part Ⅲ total score (r=0.398, P<0.01), UPDRS part IV total score (r=0.375 P<0.01). (6) Stepwise multiple regression analysis shows that the impact of the number of occurrence of NMS in order mainly depends on UPDRSI score and UPDRS II scores.CONCLUSIONS:(1) The incidence rate of no-motor symptoms is high among PD patients. And the incidence of autonomic nerves disorders was the highest(97.0%). Among 67 cases of PD, constipation, insomnia, memory loss, depression, anxiety, difficulty concentrating, vivid dreams, sweating are the most common NMS.(2) Significant relationship can be seen between sleep disorders and H-Y stage in all types of NMS. The incidence rate of Voiding dysfunction, lower extremity edema, difficulty swallowing, difficulty concentrating, delusions, hallucinations, apathy are related to H-Y stages. (3) There are gender differences non-motor symptoms among PD patients; (4) There was a positive correlation between the incidence rate of NMS and age, age of onset, H-Y rating, total UPDRS score, UPDRS part I total score, UPDRS part II total score, UPDRS part Ⅲ total score, UPDRS part IV total score. (5) In order, the spirit, behavior and mood disorders and daily movement disorder are the mainly infiuencing factors of the number of occurrence of NMS in PD.