Analysis Of Clinical Characteristics And Prognostic Factors Of Ewing’s Sarcoma Family Of Tumors

Objective We retrospectively analyzed the clinical feature and therapy of Ewing’s sarcoma family of tumors(ESFT) in 13 year. Deepening the understanding of ESFT and gain experience by analysis the prognostic factors.Methods Collecting patients enrolled from January 1992 to October 2015 in Cancer Hospital Affiliated to Guangxi Medical University and confirmed by pathology to make a statistical analysis.Results 68 patients with median follow-up time was 45.5months(7-158 months), median age of onset was20years(3-77years).≤20years account for51.4%. Central axis was more than limbs(70.6%vs29.4, respectively).The positive rates of CD99 and FLI-1 were respectively 96.4%、92.3%.The median survival of metastasis and non-metastasis were respectively 12 months and 25 months. Univariate analysis showed that treatment protocols, chemotherapy and clinical stages were relative factors of prognosis (P<0.05). Multivariate cox regression analysis suggested chemotherapy and clinical stages were independent prognostic factors for ESFT (P<0.05). The survival of Comprehensive treatment was longer than single treatment in metastasis (χ2=6.383, P=0.012),but no no statistical significance was observed in non-metastasis (χ2=2.698, P=0.101).Conclution Ewing’s sarcoma family of tumors is high malignant small round cell tumors with short survival and poor prognosis. Chemotherapy and clinical stages were independent prognostic factors.Comprehensive treatment improves the survival of ESFT.