Retrospective Analysis Of The Functional Disorder Of Gastrointestinal Function In Patients With Diabetes Mellitus

Objective(s):To analysis the related data of diabetic patients with diabetic gastrointestinal dysfunction and non gastrointestinal dysfunction of diabetes patients, investigate the related factors of gastrointestinal dysfunction in patients with diabetes mellitus,and provide guidance for the prevention of the development of gastrointestinal dysfunction in patients with diabetes.Methods:180 patients from the Second Affiliated Hospital of Kunming Medical University in 2006 to 2015, among them,80 were diagnosed as diabetic gastrointestinal dysfunction, set as the case group; 100 patients with diabetes who were not diagnosed with diabetic gastrointestinal dysfunction, is set as the case group. Compare the two groups of gender、age, medical history, islet function (C-peptide release test)、glycosylated hemoglobin%、 fasting blood-glucose postprandial 2 hours blood glucose、diabetic complication (diabetic nephropathy, diabetic eye disease, coronary heart disease, diabetic ketosis and cerebral artery elasticity, peripheral vascular atherosclerosis, diabetic peripheral neuropathy) and other related indicators.Results:Sex of the case group compared with the control group,there was no significant difference between the two groups, P=0.083.The case group 0 hours c-peptide,1 hours C- peptide,2 hours C- peptide were lower than the control group [The 0 hour C- peptide was (1.79±1.54ng/ml) vs (1.98±1.20 ml), P=0.367, The difference was not statistically significant; The 1 hour C- peptide was (2.86±2.33 ng/ml)vs(3.97±2.77 ng/ml), P=0.05, The difference was statistically significant; The 2 hour C- peptide was (3.33±2.58 ng/ml) vs (8.44±3.62 ng/ml), P<0.001, The difference was statistically significant]. The history of case group was higher than that of control group[(11.25±6.34) vs (7.69±6.80), P<0.001], The difference was statistically significant. The age of case group was higher than that of the control group [(59.83±15.14) vs (53.57±13.00), P=0.90], The difference was not statistically significant. The fasting blood glucose was lower in the case group than in the control group [(8.53±3.61mmol/L) vs (9.10±3.70mmol/L), P=0.30], The difference was not statistically significant. The blood sugar of the case group was lower than that of the control group 2 hours after meal [(13.21±4.60mmol/L)vs(14,51±5.46mmol/L),P=0.09], The difference was not statistically significant. The hemoglobin of case group was higher than that of the control group [(10.29±3.50)vs(9.66±2.78), P=0.18], The difference was not statistically significant. The proportion of peripheral atherosclerosis in the case group was higher than that in the control group [61.25%vs59%± P=0.88], The difference was not statistically significant. The proportion of patients with coronary heart disease in the case group was higher than that in the control group [25%vs7%, P=0.01], The difference was statistically significant. The proportion of the cerebral artery elasticity in the case group was higher than that in the control group[26.25%vs24%, P=0.73], The difference was not statistically significant. The proportion of diabetic nephropathy in the case group was higher than that in the control group [37.5%vs16%, P=0.02], The difference was statistically significant. The proportion of diabetic eye disease in the case group was higher than that in the control group[45% vs15%, P<0.001], The difference was statistically significant. In case group, diabetic ketosis proportion is higher than that of control group [22.5%vs20%, P=0.72]. The difference was not statistically significant. The proportion of peripheral nerve lesions in the case group was higher than that in the control group [51.25%vs21%, P<0.001], The difference was statistically significant.Conclusion(s):The occurrence of diabetic gastrointestinal dysfunction have relevance with islet function, history, diabetes mellitus complicated with coronary heart disease, diabetic nephropathy, diabetic eye disease, peripheral neuropathy. the patients with bad islet function, long history of disease, complicated with coronary heart disease, diabetic nephropathy, diabetic eye disease, peripheral neuropathy more likely to be associated with diabetic gastrointestinal disorders. However, the diabetic gastrointestinal dysfunction did not have significantly correlation with age, glycosylated hemoglobin, fasting blood glucose, postprandial 2 hour blood glucose, diabetes ketosis, peripheral vascular atherosclerosis.