The Study Of Early Postoperative Immune Function In Patients With Non Small Cell Lung Cancer Treated By Open Chest Surgery And Video-assisted Thoracoscopic Surgery

Objective:To detect the changes of serum levels of, CD4+T, CD8+T,CRP and Chemerin in peripheral serum of patients with different surgical methods on the immune function of patients.Methods:The clinical data of patients with early non small cell lung cancer who were treated by open chest or video-assisted thoracoscopic surgery in our department from October 2015 to March 2016 were collected. Preoperative, postoperative 24 h, 72 h, and 120h peripheral blood were examined in all patients before and after operation. To compare the two groups in the above indicators.Results:60 cases of non small cell lung cancer patients, including 30 cases of Video-assisted Thoracoscopic Surgery group,30 cases of open chest group surgery. Which the proportion of CD4+T cells:postoperative 24h, postoperative 72h of two groups of patients were compared with the preoperative appear different degree is reduced (P<0.05); postoperative 120h, Video-assisted Thoracoscopic Surgery group compared with preoperative no statistical significance (P>0.05); but in group compared with the preoperative difference was statistically significant (P<0.05). The proportion of CD8+T cells:Video-assisted Thoracoscopic Surgery group in the site changed little (P<0.05), and in group after 24h compared with the preoperative decreased (P<0.05). CRP concentration changes:two groups of patients at each time point were significantly increased compared with the preoperative (P<0.001). Chemerin concentration:postoperative 24h and preoperative contrast increased (P< 0.05); postoperative 72h in Video-assisted Thoracoscopic Surgery group and preoperative contrast decreased significantly (P< 0.001), open chest Surgery group and the preoperative contrast decreased (P< 0.05). Postoperative 120h, before the two groups of patients with serum Chemerin concentration of contrast were decreased significantly (P<0.001), Video-assisted Thoracoscopic Surgery group comparing postoperative 72h decline was not significant (P>0.05), after open chest Surgery group compared with 72h decreased with statistical significance (P<0.05).Conclusion:VATS is associated with reduced acute inflammatory responses and immunosuppression compared with OP. Chemerin can be used as a potential marker for the immune and inflammatory response in patients with lung cancer.