Clinical Research Of Relationship Of The D-dimer And Fibrinogen Level In Patients Of The Sudden Sensorineural Hearing Loss

Objective:To explore the correlation between the occurrence of sudden sensorineural hearing loss and the microcirculation disorder,by analyzing the levels of serum D-dimer and fibrinogen in patients suffered from different frequency hearing lose with sudden deafness before treatment.We wonder if they could become clinical and biological indicators for thrombolytic therapy of sudden sensorineural hearing loss,as to provide theoretical basis for the study of the appropriate treatment of sudden deafness according to different frequency hearing loss.Methods:101 patients diagnosed as sudden deafness and hospitalized in the Department of Otolaryngology of the Second Affiliated Hospital of Kunming Medical University from March 2014 to March 2016 were selected as the research objects,of which male 47 cases(46.50%),female 54 cases (53.50%),and the mean age was 35±8.6 years.They all conformed to the diagnostic criteria of "The diagnosis and treatment guidelines of Sudden Sensorineural Hearing Loss" of the Chinese Medical Association Department of Otorhinolaryngology in 2015.The 101 patients clearly diagnosed as sudden deafness were divided into four groups according to the frequency and degree of hearing loss shown in the hearing threshold curves of pure tone audiometry: ①low-tone type:20 cases;②high-tone type:22 cases;③flat type: 33 cases;④completely deafness type (including extremely severe hearing loss):26 cases. The normal control group contains 98 cases,of which male 60 cases (61.20%),female 38 cases (38.80%),and the mean age was 35.67±11.34 years.The levels of serum D-dimer and fibrinogen of each group of sudden deafness and the control group were measured respectively before treatment,and were analyzed statistically.Results:①The levels of serum D-dimer of the patients with sudden deafness in the flat type group and the high-tone type group were significantly higher than the control group,and the difference was statistically significant. (P<0.05); The levels of serum D-dimer of the patients with sudden deafness of the low-tone type group and the completely deafness type (including extremely severe hearing loss) group showed no significant difference compared with the control group(P>0.05).②The levels of serum D-dimer of the four groups of the patients with sudden deafness showed no statistical differences between each other(P>0.05). ③The levels of serum fibrinogen of the patients with sudden deafness in the low-tone type group, the high-tone type group, the flat type group,and the completely deafness type (including extremely severe hearing loss) had no significant difference compared with the control group(P>0.05).Conclusion:The levels of serum D-dimer in different groups of patients with sudden deafness have statistical differences.The levels of serum D-dimer of patients with sudden deafness in the flat type group and the high-tone type group were significantly higher,which may be related to the imbalance of coagulation and fibrinolysis system.Monitoring the levels of serum D-dimer and fibrinogen may have important clinical significance for different treatment schemes of sudden deafness.