The Clinical Study Of Naoluotong Granule In The Treatment On Atherosclerosis With Liver-kidney Deficiency And Phlegm-blood Stasis

Objective:By observing the effect of Naoluotong Granule on TCM syndrome score, carotid intima-media thickness,resistance index,plaque area, blood lipids, blood and inflammatory cytokines of atherosclerosis patients with liver-kidney deficiency and phlegm-blood stasis, this paper is to evaluate the clinical efficacy of Naoluotong Granule, and to explore the mechanismof action of Naoluotong Granule in treating the patients with atherosclerosis.Methods:40 inclusion-criteria atherosclerosis patients with liver-kidney deficiency and phlegm-blood stasis are chosen. They are randomly divided into treatment group of 20 patients and the control group of 20 cases. The control group receiveonly the standardWestern medicine treatment, while the treatment group take Naoluotong particlesfor a month besides the standardWestern medicine treatment. The clinical efficacy of Naoluotong Granule are analyzed by observing and comparingthe before and after treatment changes in patients’ TCM syndrome score, carotid intima-media thickness, resistance index, plaque area, lipid, variable changes in blood flow and inflammatory factors.Results:(1)In TCM syndrome, the clinical symptoms of both the treatment group and the control group showed significant improvement (P<0.05). The treatment group:total effective rate was 90%, including marked effective 15%, effective 75% and ineffective10%; the control group:the total effective rate was 70%, including 70% effective,25%ineffective, and aggravation5%. The improvement degree of the treatment group is obvioulsy better than the control group (P<0.05). (2) In the aspects of carotid intima-media thickness, resistance index, blood lipids, blood, inflammatory cytokines, both groups showed significant improvement (P <0.05) after treatment, and the improvementdegree of treatment group is better than the control group (P<0.05). (3) In terms of the impact on liver and kidney function, there was no significant difference before and after treatment (P>0.05).Conclusion:Naoluotong Granule can improve the clinical symptoms of atherosclerosis patients. It can retard atherosclerosis occurrence anddevelopmentby improving carotid artery intima-media thickness, resistance index, lipid levels, blood levels of inflammatory cytokines. Naoluotong Granule with good drug safety, is a clinically effective prescription treatment of atherosclerosis.