| Objective Irritable bowel syndrome (IBS) is a commonly seen chronic functional gastrointestinal disease that is characteristic of abdominal pain, abdominal discomfort, and changes of stool character as well as bowel evacuation habit, with IBS-D being the most commonly seen subtype. It has been reported at home and abroad in recent years that exercise intervention therapy achieves good therapeutic effects. The research observes the effects of exercise intervention on the psychological states, symptoms together with life quality of IBS-D patients, and understand the variation of expression levels of interleukin 6 and interleukin 10 in the serum of IBS patients through aerobic exercise intervention therapy with moderate intensity for 12 weeks, and the results verify that exercise is a simple and effective non-drug method to treat IBS. Methods Diarrhea IBS patients that were treated in the gastroenterology department outpatient of a top three hospital in Yangzhou were selected through convenience sampling in the research. The patients who met the inclusion criteria were divided into the blank control group (20cases), drug intervention group (32 cases) and exercise intervention group (30cases). The major measures in the exercise intervention group were as follows:explanation of the basic knowledge of IBS as well as the relevant theoretical knowledge of aerobic exercise intervention, and formulation of individualized moderate prescription of aerobic exercise intervention, with the total intervention duration of 12 weeks. The patients in the drug intervention group took anxiolytics rather than exercises according to the medical advice. The patients in the blank control group took no exercise, and they had normal life as usual. The patients in two groups completed the baseline investigation of the IBS life quality scale, IBS symptom severity scale, SAS scale, and SDS scale, together with the determination of serum interleukin 6 and interleukin 10. The patients in the three group were followed up once a month. Statistical analysis and comparison of all data in the three groups were conducted upon the end of the intervention (the twelfth weekend), and finally the results and conclusion were drawn. Result 1.SAS and SDS self-rating anxiety scale:the scores of IBS-D patients in the drug and exercise intervention groups decreased at the end of the 12th week, with significant differences among groups (P<0.05), while there was no significant difference of the scores in the exercise intervention group when compared with the drug intervention group (P>0.05).2.IBS-SSS scale:the total scores, abdominal pain scores, length of abdominal pain scores, abdominal distension scores, life satisfaction scores increased after intervention, with significant differences among groups (P<0.05), while there were no differences of defecation satisfaction scores, with no significant differences among groups (P>0.05). The scores of abdominal pain severity, length of abdominal pain, and abdominal distension showed significant differences in the drug intervention group and exercise intervention group (P<0.05), but with no significant differences of defecation satisfaction and life satisfaction (P>0.05). The symptom severity in the three groups showed significant differences (P<0.05). There were significant differences of the total effective rates in the drug intervention group and exercise intervention group at the end of the 12th week (P<0.05).1 patient recovered in the exercise intervention group, accounting for 3.3%, with the treatment effective rates of the exercise intervention group and the drug intervention group being 66.7% and 40.6%, respectively.IBS-QOL scale:The total scores of IBS-QOL increased after intervention, with significant differences among groups (P<0.05). Further pairwise comparison of LSD indicated significant differences (P<0.05).8-dimension comparison revealed that all dimensions except one (sexual behavior, P>0.05) showed significant differences (P<0.05). Pairwise comparison demonstrated that there were no significant differences in the five dimensions which were anxiety, body consciousness, health concern, social function, and sexual behavior (P>0.05), while there were significant differences in behavior disorder, picky eating and interpersonal relationship (P<0.05).Inflammatory factor:The expression level of IL-6 reduced in the drug intervention group and the exercise intervention group after intervention, with significant differences among groups (P<0.05), and further pairwise comparison of LSD indicated significant differences between the two groups (P<0.05). There was no change of the IL-10 expression level after intervention, with no significant differences among groups (P>0.05).Conclusion 1 Moderate aerobic exercise effectively reduced anxiety and depression levels, and improved negative emotion in IBS-D patients; what’more, when compared with pure anxiolytics, it achieved similar effects with drugs in improving anxiety and depression.2.Moderate aerobic exercise effectively relieved the symptoms of IBS-D patients, especially for the degree and frequency of abdominal pain, degree of abdominal distension and life satisfaction; however, it had poor effects on improving defecation. The effects of symptom relieving were better than that in the drug group, regardless of there being difference of total effective rate.3.Moderate aerobic exercise remarkably enhanced the life quality of IBS-D patients, and improved the interpersonal relationship, behavior disorder and picky eating of the patients when compared with the drug group.4.Moderate aerobic exercise reduced the expression level of pro-inflammatory factor and enhanced the expression level of the anti-inflammatory factor, indicating that the probable mechanism of IBS-D treated with exercise intervention may be the correction of the balance between pro-inflammatory and anti-inflammatory factors.5.It had been verified that moderate aerobic exercise, which had certain effects on IBS-D patients, was a simple safe and convenient method for treating IBS. It was well accepted by the objects of study and was worthy of clinical application. |
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