Clinical Observation And Experimental Study On The Treatment Effect Of Sheng Wei Prescription To CAG

Objective:This research is designed to evaluate the curative effect of the Modified Sheng Wei Fang prescription by two parts, or clinical study and zoopery. It is also designed to analysis whether there is a promotion role by join the leeches based on the Sheng Wei Fang prescription. And though a preliminary discussion on the mechanism of action of the treatment of chronic atrophic gastritis, we expect that it can provide a basis for its clinical application Methods:Clinical study:Through prospectie randomized controlled method, sixty patients were divided randomly into two groups, who have were diagnosed the chronic atrophic gastritis. The treatment group was treated with the Sheng Wei prescription and dried leech, while the control group was treated by Sheng Wei prescription. The course of treatment is half a year. Then review the gastroscope and to compare the clinical symptoms, endoscopic characteristics and pathological effect of patients in the two groups by statistical methods.Zoopery:Ninety SD rats were divided into blank group and model group(15 in blank group and 75 in model group). The rats in blank group were feed freely by 200μg/mL N-methyl-N-nitro-N-nitrosoguanidine reagent, cooperating the hunger method. Then divide the model group into new model group, the group of Wei Fu Chun, the group of Sheng Wei prescription, the group of dried leech and the group of Sheng Wei prescription associate with dried leech. Every group had 15 rats and be feed with corresponding pharmacals for 9 weeks. Take out the gastric mucosal tissue of rats and observe the change of pathological tissue, at the same time, checking the content of CD4+、CD8+ in blood serum. Results:Clinical study:(a), Symptomatic effects:Total effective rate were both 96.67% in two groups of patients, but the markedly effective rate of the original group was 90.00%, and the modified group was 70.00%, two groups have great difference, (b), Gastroscope curative effects:Total effective rate in the modified group was 90.00%, while the original group was 66.67%, the modified group was significantly higher than the original group(P< 0.05). (c), Pathological effect:Total effective rate in two group were 93.33% and 76.67% respectively, there was no statistically significant difference (P>0.05), while markedly effective rate of the two groups were 73.33% and 40.00% respectively, the significant difference (P<0.05).Zoopery:By treated with drugs after successly modeled, the Sheng Wei prescription group, the leech group and the modified group had shown some improvement effects on atrophy of gastric mucosal, and improvement is the best in the modified group(P<0.05). Three groups also had shown some improvement effects on immune function of the rat models, however, the differences is no significance. Conclusion:Sheng Wei prescription has a good treatment effect on chronic atrophic gastritis. Not only it can improve the symptoms, but also can reverse histopathological changes, such as atrophy, metaplasia hyperplasia and some intestinal. The effects had improved after dried leech was added in. We speculate that, the mechanism may be associated with the improvement of immune functions. it deserved a further study.