| Objective:1. Analysis of 301 cases of patients with subclinical hypothyroidism physical features of traditional Chinese medicine and TCM syndrome type distribution.2. Evaluation of pinellia magnolia bark decoction add and subtract to nitrogen in resistance syndrome in patients with subclinical hypothyroidism is effective and safety.Methods:1.301 patients with subclinical hypothyroidism TCM physique observation:in February 2014 to March 2016, China academy of traditional Chinese medicine guang an men hospital screening of subclinical hypothyroidism endocrine clinic high-risk groups, 667 cases, in accord with standard of diagnosis in 301 cases. Patients fill in subclinical hypothyroidism patients physical features research scale, TCM symptoms, tongue and pulse condition, constitution of traditional Chinese medicine, such as data collection, a database of all the data, using SPSS 20.0 statistical analysis software to all the data for statistical analysis. Descriptive statistical methods to analyze the traditional Chinese medicine symptoms, tongue and pulse condition, TCM constitution, system clustering analysis method is used for TCM symptoms, tongue and pulse condition for clustering analysis.2. Nitrogen/resistance syndrome clinical intervention studies:a randomized, double-blind, placebo parallel controlled clinical trial design. In May 2015 to March 2016, China academy of traditional Chinese medicine into the guang an men hospital endocrine clinic nitrogen/resistance the 50 patients with subclinical hypothyroidism. Due to this test plan to collect 72 cases with nitrogen to resistance syndrome in patients with subclinical hypothyroidism, finish the 50 cases, now do not conform to the requirements of the jie blind. By the third party of 50 cases of nitrogen in resistance the subclinical hypothyroidism patients were grouped, divided into group 1 and group 2.24 cases of group 1, group 226 cases, two groups adopt the general basis of aftercare lifestyle interventions, treatment group given pinellia magnolia bark tonga subtraction formula granules, the control group given a placebo, before meals,2 times a day,4 grams at a time. No currently jie blind, group 1, group 2 were given shape, color, smell and packaging the same drugs (2 times each day,4 g) intervention in 12 weeks. Observation group 1, group 2 on thyroid function, thyroid antibodies, blood lipids and the influence of safety index. For group 1 and group 2 patients during every 4 weeks to review three iodine in serum free thyroid original amino acid, serum free thyroid hormone, thyroid stimulating hormone, three four iodine thyroid iodine thyroid original glycine, the original glycine, thyroglobulin antibody resistance, resistance to thyroid peroxidase antibody, total cholesterol, triglycerides, high-density lipoprotein cholesterol (hdl-c), low density lipoprotein cholesterol (hdl-c), alanine aminotransferase, aspartate aminotransferase, urea nitrogen, creatinine, and electrocardiogram (ecg), and records of TCM symptoms and quality of life scale. For the whole test process in strict management and quality control. A database of all the data, using SPSS20.0 statistical analysis software for all data for statistical analysis. More data comparison with analysis of variance between groups, two two compared with t test, the percentage of comparison with X2 test.Result:1.301 cases of patients with subclinical hypothyroidism frequency of syndromes of the top 10, in turn, is god fatigue, dry mouth dry throat, two eye dryness, shortness of breath, lumbar debility, good heave a deep sigh, dry skin, back pain, decreased visual acuity, dizziness.2.301 cases of patients with subclinical hypothyroidism tongue, pulse condition and frequency of top five, in turn, whitish, tongue is red, moss, moss thin yellow, pulse fine.3. According to the results of cluster analysis, in combination with the practical situation of clinical and subclinical hypothyroidism in patients with TCM syndrome type distribution in diseases with ease and liver, spleen and kidney deficiency syndrome, Yin deficiency syndrome of liver Yin deficiency syndrome, insufficient JingXie primarily.4. In 301 patients with subclinical hypothyroidism, single physique of 109 cases of patients,36.2%of the total; Complex patients with 192 cases, accounting for 63.8%of the total. Single body with gentle temperament, qi deficiency, Yang deficiency, Yin deficiency, qi depression is seen. Complex distribution, two kinds of compound existing in the constitution, with qualitative, Yin qi depression compound for see, three kinds of compound existing in the constitution, with qi deficiency, qi depression, Yang compound for see, four kinds of compound existing in the constitution, qi deficiency in quality, quality, Yang qi depression, phlegm wet composite for see,5 kinds of compound existing in the constitution, with qi deficiency, qi depression, mass transfer, Yang deficiency, phlegm wet mass and blood stasis compound for see,6 kinds of compound existing in the constitution, qi deficiency in quality, quality, Yang qi depression, phlegm wet mass, blood stasis, hot and humid mass composite for see, seven kinds of compound existing in the constitution, qi deficiency in quality, quality, Yang qi depression, phlegm wet mass, blood stasis, hot and humid compound quality, Yin quality is seen, eight kinds of compound existing in the constitution, qi deficiency in quality, quality, Yang qi depression, phlegm wet mass, blood stasis, hot and humid quality, Yin quality, great quality, and the compound is seen.5. TSH changes:group 1, TSH statistically significant differences before and after treatment (P< 0.05); The difference between group 1 and group 2 difference statistically significant (P< 0.05).6. TCM symptoms are:group 1, before and after treatment of TCM symptom score difference was statistically significant (P< 0.05); The difference between group 1 and group 2 difference statistically significant (P< 0.05), group 1 fruit better than group 2.7. The quality of life score comparison:after treatment group 1 health change, physiological function, physical function, emotional function, social function, energy and health groups before treatment significantly improved (P< 0.05); Group 1 health change, physiological function, physiological function, emotional function, social function, energy and health status before and after treatment interclass difference compared with group 2, the difference was statistically significant (P< 0.05).8. The symptoms of TCM curative effect comparison:group 122 cases were markedly improved after treatment,1 case effectively,0 case ineffective; Group 20 cases were markedly improved after treatment, the effective 4 cases,21 cases.9. Other laboratory indexes:group 1 patients with total cholesterol, triglycerides, high-density lipoprotein cholesterol (hdl-c), low density lipoprotein, thyroglobulin antibody resistance, resistance to thyroid peroxidase antibody showed downward trend after TCM treatment.10. Safety indicators:group 1, group 2, treatment before and the day after tomorrow aspartic acid transaminase difference is not statistically significant (P> 0.05); Group 1, group 2, before and after treatment alanine aminotransferase difference is not statistically significant (P> 0.05); Treatment group 1, group 2, no statistically significant difference before and after the treatment of creatinine (P> 0.05); Group 1, group 2, before and after treatment of urea nitrogen difference is not statistically significant (P> 0.05).Conclusion:1.301 cases of patients with subclinical hypothyroidism physical distribution of composite is greater than a single mass, compound quality in both constitution compound and three physical compound is the most common.2. A single physique of 109 cases of patients,36.2% of the total; Complex patients with 192 cases, accounting for 63.8% of the total.3. Two kinds of compound existing in the constitution to qi depression compound quality, Yin quality is seen, three kinds of compound existing in the constitution, with qi deficiency, qi depression, Yang composite is seen.4.301 cases of subclinical hypothyroidism in patients with TCM syndrome type distribution to diseases with ease and liver, spleen and kidney deficiency syndrome, Yin deficiency syndrome of liver Yin deficiency syndrome, insufficient JingXue primarily.5. Group 1 of the medicine in the treatment of subclinical hypothyroidism, can promote the recovery of thyroid function, improve immune function and blood lipid disorders, can improve the patient’s clinical symptoms, and security is good, beneficial to patients with subclinical hypothyroidism. |
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